Title:
PROCESS FOR PRODUCING 4-AMINO-2-ALKYLTHIO-5-PYRIMIDINECARBALDEHYDE
Document Type and Number:
WIPO Patent Application WO/2006/115237
Kind Code:
A1
Abstract:
An industrially advantageous process for 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde production by which a 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde can be easily produced in a high yield; an intermediate compound for use in the process; and an industrially advantageous production process by which the intermediate compound can be easily and safely produced in a high yield. A process for producing an alkali metal salt of a 3,3-dialkoxy-2-hydroxymethylenepropanenitrile is provided which is characterized by reacting at least one nitrile compound selected from the group consisting of 3,3-dialkoxypropanenitriles and 3-alkoxy-2-propenenitriles with a formic ester at -10 to 30°C in the presence of a base containing an alkali metal. Also provided are: an alkali metal salt of 4-amino-2-mercapto-5-pyrimidinecarbaldehyde; a process for producing the alkali metal salt of 4-amino-2-mercapto-5-pyrimidinecarbaldehyde which is characterized by reacting the 3,3-dialkoxy-2-hydroxymethylenepropanenitrile alkali metal salt with thiourea; a process for producing a 4-amino-2-alkylthio-5-pyrmidinecarbaldehyde which is characterized by reacting the 4-amino-2-mercapto-5-pyrmidinecarbaldehyde alkali metal salt with an alkylating agent; and a use of the 4-amino-2-mercapto-5-pyrimidinecarbaldehyde alkali metal salt in producing the 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde.
Inventors:
NISHINO SHIGEYOSHI
SHIKITA SHOJI
MURAKAMI TADASHI
SHIKITA SHOJI
MURAKAMI TADASHI
Application Number:
PCT/JP2006/308507
Publication Date:
November 02, 2006
Filing Date:
April 24, 2006
Export Citation:
Assignee:
UBE INDUSTRIES (JP)
NISHINO SHIGEYOSHI
SHIKITA SHOJI
MURAKAMI TADASHI
NISHINO SHIGEYOSHI
SHIKITA SHOJI
MURAKAMI TADASHI
International Classes:
C07C253/30; C07C255/15; C07D239/47
Foreign References:
| JP2004507540A | 2004-03-11 | |||
| JPS6019755A | 1985-01-31 | |||
| JPS446250B1 | ||||
| JPS295376B1 |
Attorney, Agent or Firm:
Tsukuni, Hajime (22-12 Toranomon 1-chome Minato-ku, Tokyo 01, JP)
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