PROCESS FOR PRODUCING 4-SUBSTITUTED-2-NITRO-FLUOROBENZENES

WIPO Patent Application WO/2000/003971

A1

A process for selectively eliminating a compound of general formula (II) from a mixture of a compound of general formula (I) with the compound of general formula (II). This process comprises reacting the compound of general formula (II) with a tertiary amine and a nucleophilic agent and then washing and/or crystallizing the thus obtained compound to thereby separate the same from the mixture. A process for producing a compound represented by general formula (I) which is free from any mutagen is also provided. In these formulae, R?1¿ represents alkyl, alkyl carbonyl or alkoxycarbonyl; and Hal represents halogeno.

MUNAKATA MIKIO (JP)
SUMI SHINJIRO (JP)
MURAI YASUSHI (JP)
IINUMA KATSUHARU (JP)

PCT/JP1999/003825

January 27, 2000

July 15, 1999

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MEIJI SEIKA KAISHA (JP)
NEUROSEARCH AS (DK)
MUNAKATA MIKIO (JP)
SUMI SHINJIRO (JP)
MURAI YASUSHI (JP)
IINUMA KATSUHARU (JP)

C07C201/08; C07C201/16; C07C205/12; C07C205/37; C07C205/38; C07C205/43; C07C205/45; C07C205/58; C07D401/10; (IPC1-7): C07C201/16; A61K31/44; C07C201/08; C07C205/45; C07C205/58; C07D205/12; C07D401/10

WO1998017651A1

1998-04-30

JPH0871413A	1996-03-19
JPH072838A	1995-01-06

SUZUKI HITOMI ET AL: "Ozone-mediated nitration of chloro- and bromobenzenes and some methyl derivatives with nitrogen dioxide. High ortho-directing trends of the chlorine and bromine substituents", J. CHEM. SOC., PERKIN TRANS., vol. 2, no. 3, 1994, pages 479 - 484, XP002926606
See also references of EP 1097918A4

Sato, Kazuo (Fuji Bldg. 2-3 Marunouchi 3-chome Chiyoda-ku, Tokyo, JP)

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