Title:
PROCESS FOR PRODUCING 5-AMINO-8- ALKYLQUINOLO NECARBOXYLIC ACID DERIVATIVES AND INTERMEDIATES IN THE PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/2000/055116
Kind Code:
A1
Abstract:
A process for producing intermediates of antibacterial agents in accordance with the schema (I), (III), (IV), (V), (VI) and (VII) and intermediates in the production thereof, wherein R?1¿ represents hydrogen or nitro; R?2¿ represents C¿1-6? alkyl; R?3¿ and R?4¿ represent each C¿1-6? alkyl, or R?3¿ and R?4¿ may form together with the nitrogen atom to which they are bonded a 5- or 6-membered cyclic structure optionally containing oxygen, nitrogen, sulfinyl or sulfonyl as a ring-constituting element; R?6¿ represents C¿3-6? halogenocycloalkyl; X?1¿ represents halogeno or hydrogen; X?2¿ and X?3¿ represent each a leaving group; and Y represents C¿1-6? alkyl or C¿2-6? alkenyl.
Inventors:
TAKEMURA MAKOTO (JP)
TAKAHASHI HISASHI (JP)
TAKAHASHI HISASHI (JP)
Application Number:
PCT/JP2000/001582
Publication Date:
September 21, 2000
Filing Date:
March 15, 2000
Export Citation:
Assignee:
DAIICHI SEIYAKU CO (JP)
TAKEMURA MAKOTO (JP)
TAKAHASHI HISASHI (JP)
TAKEMURA MAKOTO (JP)
TAKAHASHI HISASHI (JP)
International Classes:
C07C229/34; C07D215/56; (IPC1-7): C07C229/34; C07C227/16; C07C227/18; C07D215/56
Foreign References:
| EP0237955A2 | 1987-09-23 | |||
| US5849757A | 1998-12-15 | |||
| US4894458A | 1990-01-16 |
Other References:
CECCHETTI, VIOLETTA ET. AL.: "Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy", J. MED. CHEM., vol. 39, no. 25, 1996, pages 4952 - 4957, XP002929619
See also references of EP 1167344A4
See also references of EP 1167344A4
Attorney, Agent or Firm:
Oguri, Shohei (Ark Mori Building 28th floor 12-32, Akasaka 1-chome Minato-ku Tokyo, JP)
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