Title:
PROCESS FOR PRODUCING BENZOTHIOPHENECARBOXYLIC ACID AMIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/050261
Kind Code:
A1
Abstract:
A process for producing compounds having PGD¿2? antagonism represented by formula (I), pharmaceutically acceptable salts thereof or hydrates of the same characterized by reacting an amino alcohol of formula (II) or its salt with a compound of formula (III) or its reactive derivative, oxidizing the obtained product in the presence of 2,2,6,6,-tetramethylpiperidine-1-oxyls, and then reacting with an ylide under Wittig reaction conditions optionally followed by deblocking.
Inventors:
HONMA TSUNETOSHI (JP)
HIRAMATSU YOSHIHARU (JP)
OKADA TETSUO (JP)
KAKINUMA MAKOTO (JP)
HIRAMATSU YOSHIHARU (JP)
OKADA TETSUO (JP)
KAKINUMA MAKOTO (JP)
Application Number:
PCT/JP1999/001617
Publication Date:
October 07, 1999
Filing Date:
March 30, 1999
Export Citation:
Assignee:
SHIONOGI & CO (JP)
HONMA TSUNETOSHI (JP)
HIRAMATSU YOSHIHARU (JP)
OKADA TETSUO (JP)
KAKINUMA MAKOTO (JP)
HONMA TSUNETOSHI (JP)
HIRAMATSU YOSHIHARU (JP)
OKADA TETSUO (JP)
KAKINUMA MAKOTO (JP)
International Classes:
C07B61/00; C07C213/00; C07C213/02; C07C215/42; C07D333/68; C07D333/64; (IPC1-7): C07D333/68; C07C213/00; C07C213/02; C07C215/42
Domestic Patent References:
| WO1998025919A1 | 1998-06-18 |
Other References:
TSURI T, ET AL.: "BICYCLO¬2.2.1¾HEPTANE AND 6,6-DIMETHYLBICYCLO¬3.1.1¾HEPTANE DERIVATIVES: ORALLY ACTIVE, POTENT, AND SELECTIVE PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 40, 1 January 1997 (1997-01-01), US, pages 3504 - 3507, XP002927764, ISSN: 0022-2623, DOI: 10.1021/jm970343g
SENO K, HAGISHITA S: "THROMBOXANE A2 RECEPTOR ANTAGONISTS. III. SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 6,6-DIMETHYLBICYCLO¬3.1.1¾HEPTANE DERIVATIVES WITH A SUBSTITUTED SULFONYLAMINO GROUP AT C-2", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 37, no. 06, 1 January 1989 (1989-01-01), JP, pages 1524 - 1533, XP002927765, ISSN: 0009-2363
See also references of EP 1069123A4
SENO K, HAGISHITA S: "THROMBOXANE A2 RECEPTOR ANTAGONISTS. III. SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 6,6-DIMETHYLBICYCLO¬3.1.1¾HEPTANE DERIVATIVES WITH A SUBSTITUTED SULFONYLAMINO GROUP AT C-2", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 37, no. 06, 1 January 1989 (1989-01-01), JP, pages 1524 - 1533, XP002927765, ISSN: 0009-2363
See also references of EP 1069123A4
Attorney, Agent or Firm:
Aoyama, Tamotsu (Shiromi 1-chome Chuo-ku, Osaka-shi Osaka, JP)
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