Title:
A PROCESS FOR PRODUCING A BIOTIN INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO/2023/141901
Kind Code:
A1
Abstract:
A process for producing thiolactone compounds, or geometrical isomers thereof or geometrical isomeric mixtures thereof is provided. The process avoids expensive reagents, improves yield and thus is more efficient and suitable in industry.
Inventors:
GAO BO (CH)
ZHANG QIONG-MEI (CH)
PENG KUN (CH)
BONRATH WERNER (CH)
ZHANG QIONG-MEI (CH)
PENG KUN (CH)
BONRATH WERNER (CH)
Application Number:
PCT/CN2022/074427
Publication Date:
August 03, 2023
Filing Date:
January 27, 2022
Export Citation:
Assignee:
DSM IP ASSETS BV (NL)
International Classes:
C07B37/10; C07D513/00
Other References:
MASAHIKO SEKI ET AL.: "2-Thiazolidinone: a novel thiol protective surrogate of complete atom efficiency， a practical synthesis of (+)-biotin", TETRAHEDRON LETTERS, vol. 44, 31 December 2003 (2003-12-31), pages 8905 - 8907, XP004470625, DOI: 10.1016/j.tetlet.2003.09.202
MASAHIKO SEKI; MASANORI HATSUDA; YOSHIKAZU MORI; SHIN‐ICHI YOSHIDA; SHIN‐ICHI YAMADA; TOSHIAKI SHIMIZU: "A Practical Synthesis of (+)‐Biotin from L‐Cysteine", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 10, no. 23, 29 October 2004 (2004-10-29), DE, pages 6102 - 6110, XP071824001, ISSN: 0947-6539, DOI: 10.1002/chem.200400733
SEKI, M. HATSUDA, M. YOSHIDA, S.-I.: "An efficient and practical procedure for Strecker reaction: a highly diastereoselective synthesis of a key intermediate for (+)-biotin", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 45, no. 35, 23 August 2004 (2004-08-23), Amsterdam , NL , pages 6579 - 6581, XP004556593, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2004.07.034
MASAHIKO SEKI; MASANORI HATSUDA; YOSHIKAZU MORI; SHIN‐ICHI YOSHIDA; SHIN‐ICHI YAMADA; TOSHIAKI SHIMIZU: "A Practical Synthesis of (+)‐Biotin from L‐Cysteine", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 10, no. 23, 29 October 2004 (2004-10-29), DE, pages 6102 - 6110, XP071824001, ISSN: 0947-6539, DOI: 10.1002/chem.200400733
SEKI, M. HATSUDA, M. YOSHIDA, S.-I.: "An efficient and practical procedure for Strecker reaction: a highly diastereoselective synthesis of a key intermediate for (+)-biotin", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 45, no. 35, 23 August 2004 (2004-08-23), Amsterdam , NL , pages 6579 - 6581, XP004556593, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2004.07.034
Attorney, Agent or Firm:
BEIJING EAST IP LTD. (CN)
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