Title:
PROCESS FOR PRODUCING CHIRAL STATIN SIDE CHAIN INTERMEDIATES EMPLOYING CANDIDA|ANTARCTICA LIPASE B
Document Type and Number:
WIPO Patent Application WO/2013/080219
Kind Code:
A3
Abstract:
The present invention relates to an improved process for the preparation of compound of Formula-II, which is an intermediate in the preparation of HMG-CoA reductase inhibitors. wherein X is hydrogen or hydroxy protecting group and Ri is carboxyl protecting group.
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Inventors:
VAN VLIET MICHIEL CHRISTIAN ALEXANDER (IN)
SCHOEVAART WILLEM ROBERT KLAAS (IN)
SETHI MADHURESH KUMAR (IN)
MAHAJAN SANJAY (IN)
MARA BHAIRAIAH (IN)
SCHOEVAART WILLEM ROBERT KLAAS (IN)
SETHI MADHURESH KUMAR (IN)
MAHAJAN SANJAY (IN)
MARA BHAIRAIAH (IN)
Application Number:
PCT/IN2012/000770
Publication Date:
January 30, 2014
Filing Date:
November 26, 2012
Export Citation:
Assignee:
MYLAN LAB LTD (IN)
VAN VLIET MICHIEL CHRISTIAN ALEXANDER (IN)
SCHOEVAART WILLEM ROBERT KLAAS (IN)
SETHI MADHURESH KUMAR (IN)
MAHAJAN SANJAY (IN)
MARA BHAIRAIAH (IN)
VAN VLIET MICHIEL CHRISTIAN ALEXANDER (IN)
SCHOEVAART WILLEM ROBERT KLAAS (IN)
SETHI MADHURESH KUMAR (IN)
MAHAJAN SANJAY (IN)
MARA BHAIRAIAH (IN)
International Classes:
C12P7/42; C12P7/44; C12P7/62; C12P13/02; C12P17/12
Domestic Patent References:
| WO2008130638A2 | 2008-10-30 |
Other References:
JACOBSEN, E.E. ET AL.: "Enantioselective enzymatic preparation of chiral glutaric monocarboxylic acids and amides", JOURNAL OF MOLECULAR CATALYSIS. B, ENZYMATIC, vol. 21, no. 1-2, 2003, pages 55 - 58, XP002648570
PUERTAS, S. ET AL.: "Enantioselective Enzymatic Aminolysis and Ammonolysis of Dimethyl 3-Hydroxyglutarate. Synthesis of (R)-4-Amino-3-hydroxybutanoic Acid", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 61, no. 17, 1996, pages 6024 - 6027, XP002377961
LILJEBLAD, A. ET AL.: "Biocatalysis in the Preparation of the Statin Side Chain", CURRENT ORGANIC SYNTHESIS, vol. 6, no. 4, November 2009 (2009-11-01), pages 362 - 379, XP008165228
PUERTAS, S. ET AL.: "Enantioselective Enzymatic Aminolysis and Ammonolysis of Dimethyl 3-Hydroxyglutarate. Synthesis of (R)-4-Amino-3-hydroxybutanoic Acid", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 61, no. 17, 1996, pages 6024 - 6027, XP002377961
LILJEBLAD, A. ET AL.: "Biocatalysis in the Preparation of the Statin Side Chain", CURRENT ORGANIC SYNTHESIS, vol. 6, no. 4, November 2009 (2009-11-01), pages 362 - 379, XP008165228
Attorney, Agent or Firm:
NARAHARI, Babu Ambati (Anrich Industrial EstateBollaram, Jinnaram Mandal, Medak Dist, Andhra Pradesh, IN)
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