PROCESS FOR PRODUCING CIS-WHISKEY-LACTONE

Title:

PROCESS FOR PRODUCING CIS-WHISKEY-LACTONE

Document Type and Number:

WIPO Patent Application WO/1992/012143

Kind Code:

A1

Abstract:

A process for producing cis-whiskey-lactone represented by formula (A), which is one of the flavoring components of whiskey or wine, selectively and readily, which comprises hydrolyzing the lactone part of trans-whiskey-lactone with potassium hydroxide, adding an alkyl group to the product by the reaction with isopropyl bromide to form isopropyl (3S, 4S)-4-hydroxy-3-methyloctanoate, reacting the formed ester with diethyl azodicarboxylate in the presence of both triphenylphosphine and an azodicarboxylate in the presence of both triphenylphosphine and an azodicarboxylic ester to form isopropyl (3S, 4S)-4-(3', 5'-dinitrobenzoyloxy)-3-methyloctanoate, and hydrolying the formed ester with a 2 % aqueous sodium hydroxide solution.

Inventors:

EBATA TAKASHI (JP)
MATSUMOTO KATSUYA (JP)
KOSEKI KOSHI (JP)
KAWAKAMI HIROSHI (JP)
MATSUSHITA HAJIME (JP)
YOSHIKOSHI HAJIME (JP)
OKANIWA MASAKAZU (JP)

Application Number:

PCT/JP1991/001780

Publication Date:

July 23, 1992

Filing Date:

December 27, 1991

Export Citation:

Click for automatic bibliography generation Help

Assignee:

JAPAN TOBACCO INC (JP)
YUKI GOSEI YAKUHIN KOGYO KK (JP)

International Classes:

C07D307/33; C07D315/00; (IPC1-7): A61K7/46; C07D307/32

Foreign References:

JPS6341473A

1988-02-22

Other References: