Title:
PROCESS FOR PRODUCING DI(PYRIMIDINE NUCLEOSIDE 5'-)POLYPHOSPHATE
Document Type and Number:
WIPO Patent Application WO/2008/012949
Kind Code:
A1
Abstract:
Pyrimidine nucleoside 5'-triphosphoric acid is converted into pyrimidine nucleoside 5'-(cyclic triphosphoric acid) with a condensation agent. Subsequently, the pyrimidine nucleoside 5'-(cyclic triphosphoric acid) obtained is reacted with pyrimidine nucleotide in the presence of a salt of a metal selected among magnesium, manganese, and iron to synthesize di(pyrimidine nucleoside 5'-)polyphosphate. A non-protected pyrimidine nucleoside 5'-phosphoric acid compound can be used as a raw material in this process and the target di(pyrimidine nucleoside 5'-)polyphosphate can be synthesized in a yield of 50% or higher. The process is hence suitable for the mass synthesis of di(pyrimidine nucleoside 5'-)polyphosphate.
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Inventors:
KOGO, Satoru (10-1 Araoicho 2-chome, Choshi-sh, Chiba 56, 2880056, JP)
向後 悟 (〒56 千葉県銚子市新生町２丁目１０番地の１ ヤマサ醤油株式会社内 Chiba, 2880056, JP)
YAMADA, Kohei (10-1 Araoicho 2-chome, Choshi-sh, Chiba 56, 2880056, JP)
山田 浩平 (〒56 千葉県銚子市新生町２丁目１０番地の１ ヤマサ醤油株式会社内 Chiba, 2880056, JP)
IWAI, Yuko (10-1 Araoicho 2-chome, Choshi-sh, Chiba 56, 2880056, JP)
向後 悟 (〒56 千葉県銚子市新生町２丁目１０番地の１ ヤマサ醤油株式会社内 Chiba, 2880056, JP)
YAMADA, Kohei (10-1 Araoicho 2-chome, Choshi-sh, Chiba 56, 2880056, JP)
山田 浩平 (〒56 千葉県銚子市新生町２丁目１０番地の１ ヤマサ醤油株式会社内 Chiba, 2880056, JP)
IWAI, Yuko (10-1 Araoicho 2-chome, Choshi-sh, Chiba 56, 2880056, JP)
Application Number:
JP2007/000793
Publication Date:
January 31, 2008
Filing Date:
July 25, 2007
Export Citation:
Assignee:
YAMASA CORPORATION (10-1, Araoicho 2-chome Choshi-sh, Chiba 56, 2880056, JP)
ヤマサ醤油株式会社 (〒56 千葉県銚子市新生町２丁目１０番地の１ Chiba, 2880056, JP)
KOGO, Satoru (10-1 Araoicho 2-chome, Choshi-sh, Chiba 56, 2880056, JP)
向後 悟 (〒56 千葉県銚子市新生町２丁目１０番地の１ ヤマサ醤油株式会社内 Chiba, 2880056, JP)
YAMADA, Kohei (10-1 Araoicho 2-chome, Choshi-sh, Chiba 56, 2880056, JP)
山田 浩平 (〒56 千葉県銚子市新生町２丁目１０番地の１ ヤマサ醤油株式会社内 Chiba, 2880056, JP)
ヤマサ醤油株式会社 (〒56 千葉県銚子市新生町２丁目１０番地の１ Chiba, 2880056, JP)
KOGO, Satoru (10-1 Araoicho 2-chome, Choshi-sh, Chiba 56, 2880056, JP)
向後 悟 (〒56 千葉県銚子市新生町２丁目１０番地の１ ヤマサ醤油株式会社内 Chiba, 2880056, JP)
YAMADA, Kohei (10-1 Araoicho 2-chome, Choshi-sh, Chiba 56, 2880056, JP)
山田 浩平 (〒56 千葉県銚子市新生町２丁目１０番地の１ ヤマサ醤油株式会社内 Chiba, 2880056, JP)
International Classes:
C07H19/10
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (Kyodo Bldg, 3-6 Nihonbashiningyocho 1-chom, Chuo-ku Tokyo 13, 1030013, JP)
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