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Patent Searching and Data


Title:
PROCESS FOR PRODUCING FLUORINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/1997/032835
Kind Code:
A1
Abstract:
A process for producing benzyl fluoride derivatives represented by general formula (II), wherein R1 represents hydrogen, lower alkyl, etc.; R2 represents hydrogen, piperazinyl, piperidyl, pyrrolidinyl, morpholinyl, amino or heteroaryl; and R3 and R4 represent each hydrogen, halogeno, cyano, lower alkyl, or lower alkoxy, which comprises reacting a benzyl alcohol derivative represented by general formula (I), with N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine in the presence of a tertiary amine and hydrogen fluoride. This process permits fluorine compounds to be producedas efficiently as by the fluorination using DAST by inhibiting the formation of olefins and ethers as by-products.

Inventors:
SIMIZU TOSHIKAZU (JP)
NAGAOKA ATSUSI (JP)
ODA MITSUO (JP)
SEKI CHIAKI (JP)
YAMASHITA TSUNEO (JP)
SHIMOKAWA KAZUHIRO (JP)
Application Number:
PCT/JP1997/000706
Publication Date:
September 12, 1997
Filing Date:
March 07, 1997
Export Citation:
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Assignee:
EISAI KAGAKU KK (JP)
DAIKIN IND LTD (JP)
SIMIZU TOSHIKAZU (JP)
NAGAOKA ATSUSI (JP)
ODA MITSUO (JP)
SEKI CHIAKI (JP)
YAMASHITA TSUNEO (JP)
SHIMOKAWA KAZUHIRO (JP)
International Classes:
C07D295/08; C07B39/00; C07C17/16; C07C19/08; C07C22/08; C07C23/20; C07C23/28; C07C23/38; C07C253/30; (IPC1-7): C07C22/08; C07C17/16; C07C41/22; C07C43/174; C07C43/225; C07C67/307; C07C69/65; C07C233/13; C07C253/30; C07C255/33; C07C255/49; C07D295/06; C07D295/185; C07D521/00
Foreign References:
JPS61246138A1986-11-01
US3137701A1964-06-16
Other References:
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Vol. 52(11), 1979, p. 3377-3380.
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