Title:
PROCESS FOR PRODUCING FLUORINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/1997/032835
Kind Code:
A1
Abstract:
A process for producing benzyl fluoride derivatives represented by general formula (II), wherein R1 represents hydrogen, lower alkyl, etc.; R2 represents hydrogen, piperazinyl, piperidyl, pyrrolidinyl, morpholinyl, amino or heteroaryl; and R3 and R4 represent each hydrogen, halogeno, cyano, lower alkyl, or lower alkoxy, which comprises reacting a benzyl alcohol derivative represented by general formula (I), with N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine in the presence of a tertiary amine and hydrogen fluoride. This process permits fluorine compounds to be producedas efficiently as by the fluorination using DAST by inhibiting the formation of olefins and ethers as by-products.
Inventors:
SIMIZU TOSHIKAZU (JP)
NAGAOKA ATSUSI (JP)
ODA MITSUO (JP)
SEKI CHIAKI (JP)
YAMASHITA TSUNEO (JP)
SHIMOKAWA KAZUHIRO (JP)
NAGAOKA ATSUSI (JP)
ODA MITSUO (JP)
SEKI CHIAKI (JP)
YAMASHITA TSUNEO (JP)
SHIMOKAWA KAZUHIRO (JP)
Application Number:
PCT/JP1997/000706
Publication Date:
September 12, 1997
Filing Date:
March 07, 1997
Export Citation:
Assignee:
EISAI KAGAKU KK (JP)
DAIKIN IND LTD (JP)
SIMIZU TOSHIKAZU (JP)
NAGAOKA ATSUSI (JP)
ODA MITSUO (JP)
SEKI CHIAKI (JP)
YAMASHITA TSUNEO (JP)
SHIMOKAWA KAZUHIRO (JP)
DAIKIN IND LTD (JP)
SIMIZU TOSHIKAZU (JP)
NAGAOKA ATSUSI (JP)
ODA MITSUO (JP)
SEKI CHIAKI (JP)
YAMASHITA TSUNEO (JP)
SHIMOKAWA KAZUHIRO (JP)
International Classes:
C07D295/08; C07B39/00; C07C17/16; C07C19/08; C07C22/08; C07C23/20; C07C23/28; C07C23/38; C07C253/30; (IPC1-7): C07C22/08; C07C17/16; C07C41/22; C07C43/174; C07C43/225; C07C67/307; C07C69/65; C07C233/13; C07C253/30; C07C255/33; C07C255/49; C07D295/06; C07D295/185; C07D521/00
Foreign References:
JPS61246138A | 1986-11-01 | |||
US3137701A | 1964-06-16 |
Other References:
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Vol. 52(11), 1979, p. 3377-3380.
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