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Title:
PROCESS FOR PRODUCING A HYDROPHOBIC ACRYLIC POLYMER MATERIAL FOR AN OPHTHALMIC DEVICE
Document Type and Number:
WIPO Patent Application WO/2015/070981
Kind Code:
A4
Abstract:
Process for preparing a hydrophobic acrylic polymer material for the production of an implantable ophthalmic device, which process includes at least: a) a step of providing a mixture of at least an aromatic acrylate monomer, an aromatic methacrylate monomer and an alkoxyalkyl methacrylate monomer; b) a step of degassing the mixture obtained in step a); c) a step of introducing said mixture into an intraocular lens mould; d) a step of thermally induced free radical polymerization in the presence of an initiator; e) a step of polymerization by irradiation with gamma rays.

Inventors:
MEUNIER PATRICK (IT)
Application Number:
PCT/EP2014/003038
Publication Date:
July 16, 2015
Filing Date:
November 13, 2014
Export Citation:
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Assignee:
O & O MDC LTD (GB)
International Classes:
C08F220/18; A61L27/26; C08F2/46
Attorney, Agent or Firm:
SCHMIDT, Martin (15 rue Emile Zola, Lyon, FR)
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Claims:
AMENDED CLAIMS

received by the International Bureau on 6 May 2015 (06.05.2015)

1. Process for preparing a hydrophobic acrylic polymer material for the production of an implantable ophthalmic device, the glass transition temperature (Tg) of said material being between 4 and 19°C, which process includes at least:

a) a step of providing a mixture of at least an aromatic acrylate monomer, an aromatic methacrylate monomer and an alkoxyalkyl methacrylate monomer;

b) a step of degassing the mixture obtained in step a);

c) a step of introducing said mixture into an intraocular lens mould;

d) a step of thermally induced free radical polymerization in the presence of an initiator; e) a step of polymerization by irradiation with gamma rays;

f) a step of vacuum ventilation.

2. Process according to claim 1 , characterized in that step e) of polymerization by gamma radiation is performed at a dose of between 20 and 40 kGray, and preferably between 25 and 35 kGray.

3. Process according to any one of claims 1 to 2, characterized in that the step of thermally induced free radical polymerization is performed in two heat phases, the temperature of the first phase being between 40 and 70°C and the temperature of the second phase being between 1 10 and 125eC, and preferably between 1 17 and 122°C.

4. Process according to any one of claims 1 to 3, characterized in that the ventilation step f) is performed at a temperature of between 90 and 1 10°C, and preferably between 97 and

103°C.

5. Process according to any one of claims 1 to 4, characterized in that the monomer mixture includes at least:

i) between 60 and 65% of a 2-phenylethyl acrylate monomer;

ii) between 25 and 30% of a 2-phenylethyl methacrylate monomer;

iii) between 3 and 8% of an alkoxyalkyl methacrylate monomer;

iv) between 0.5 and 1 % methyl methacrylate. 6. Process according to claim 5, characterized in that the alkoxyalkyl methacrylate is 2- ethoxyethyl methacrylate. 18

7. Hydrophobic acrylic polymer material capable of being obtained by the process according to any one of claims 1 to 6.

8. Material according to claim 7, characterized in that the glass transition temperature (Tg) is between 1 1 and 13°C.

9. Material according to claims 7 or 8, characterized in that its residual content of monomers, oligomers and prepolymers is less than 0.5% by mass, preferably less than 0.3% by mass, and more preferably less than 0.1% by mass.

10. Intraocular lens blank including the polymer material according to any of claims 7 to 9, or the polymer material capable of being obtained by the process according to any one of claims 1 to 6. 1 1. Ophthalmic device including the polymer material according to any of claims 7 to 9, or the polymer material capable of being obtained by the process according to any one of claims 1 to 6.

12. Ophthalmic device according to claim 11 , wherein said device is an intraocular device.

13. Ophthalmic device according to claim 12, wherein sad device is an intraocular lens.

14. Ophthalmic device according to any of claims 11 to 13, characterized in that said device has a residual content of monomers, oligomers and pre-polymers less than 0.5% by mass, preferably less than 0.3% by mass, and more preferably less than 0.1 % by mass.

15. Ophthalmic device according to any of claims 1 1 to 14, wherein said device is essentially free of microvacuoies of a size greater than 7 pm, and preferably essentially free of microvacuoies of a size greater than 5 μιτι.