Title:
PROCESS FOR PRODUCING ISOBUTENE FROM 3-METHYLCROTONIC ACID
Document Type and Number:
WIPO Patent Application WO/2017/085167
Kind Code:
A3
Abstract:
Described are methods for the production of isobutene comprising the enzymatic conversion of 3-methylcrotonic acid into isobutene wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-methylcrotonyl-CoA into 3- methylcrotonic acid or wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-hydroxyisovalerate (HIV) into 3-methylcrotonic acid. It is described that the enzymatic conversion of 3-methylcrotonic acid into isobutene can, e.g., be achieved by making use of a 3-methylcrotonic acid decarboxylase, preferably an FMN-dependent decarboxylase associated with an FMN prenyl transferase, an aconitate decarboxylase (EC 4.1.1.6), a methylcrotonyl-CoA carboxylase (EC 6.4.1.4), or a geranoyl-CoA carboxylase (EC 6.4.1.5).
Inventors:
ALLARD MATHIEU (FR)
ANISSIMOVA MARIA (FR)
MARLIERE PHILIPPE (BE)
ANISSIMOVA MARIA (FR)
MARLIERE PHILIPPE (BE)
Application Number:
PCT/EP2016/077956
Publication Date:
June 29, 2017
Filing Date:
November 17, 2016
Export Citation:
Assignee:
GLOBAL BIOENERGIES (FR)
SCIENTIST OF FORTUNE SA (LU)
SCIENTIST OF FORTUNE SA (LU)
International Classes:
C12P5/02; C12N9/00; C12N9/10; C12N9/12; C12N9/16; C12N9/88; C12N15/52; C12P7/40
Domestic Patent References:
| WO2016034691A1 | 2016-03-10 | |||
| WO2016042012A1 | 2016-03-24 | |||
| WO2013186215A1 | 2013-12-19 | |||
| WO2014080024A2 | 2014-05-30 |
Foreign References:
| US20110053232A1 | 2011-03-03 |
Other References:
GERBLING, H.: "Peroxisomal Degradation of 2-Oxoisocaproate. Evidence for Free Acid Intermediates", BOTANICA ACTA, vol. 106, no. 5, 1993, pages 380 - 387, XP055166203, Retrieved from the Internet [retrieved on 20150130]
ABERHART, D.J. & TANN, C.-H.: "Studies on the Substrate Stereochemistry of Enoyl-CoA Hydratase (Crotonase): Nonstereospecific Hydration of beta-Methylcrotonate in Biotin-Deficient Rats", BIOORGANIC CHEMISTRY, vol. 10, no. 4, December 1981 (1981-12-01), pages 375 - 387, XP024022680
ABERHART, D.J. & TANN, C.-H.: "Studies on the Substrate Stereochemistry of Enoyl-CoA Hydratase (Crotonase): Nonstereospecific Hydration of beta-Methylcrotonate in Biotin-Deficient Rats", BIOORGANIC CHEMISTRY, vol. 10, no. 4, December 1981 (1981-12-01), pages 375 - 387, XP024022680
Attorney, Agent or Firm:
VOSSIUS & PARTNER (NO 31) (DE)
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