Title:
PROCESS FOR PRODUCING L-VALINE BENZYL ESTER P-TOLUENESULFONATE
Document Type and Number:
WIPO Patent Application WO/1999/047488
Kind Code:
A1
Abstract:
A process for producing L-valine benzyl ester p-toluenesulfonate which involves the steps of reacting L-valine with benzyl alcohol in at least one aromatic solvent selected from among toluene, monochlorobenzene and xylene in the presence of p-toluenesulfonic acid under azeotropic dehydration conditions and crystallizing L-valine benzyl ester p-toluenesulfonate from the liquid reaction mixture thus obtained. Use of this process makes it possible to safely, conveniently and industrially advantageously produce L-valine benzyl ester p-toluenesulfonate which is appropriately usable as an intermediate of drugs such as remedies for hypertension.
Inventors:
TAGAMI YAYOI
KATSURA TADASHI
ITAYA NOBUSHIGE
KATSURA TADASHI
ITAYA NOBUSHIGE
Application Number:
PCT/JP1999/001334
Publication Date:
September 23, 1999
Filing Date:
March 17, 1999
Export Citation:
Assignee:
SUMIKA FINE CHEMICALS CO LTD (JP)
International Classes:
C07C227/18; C07C229/36; C07C303/32; C07C309/39; C07C229/08; (IPC1-7): C07C229/08; C07C227/18; C07C309/30; C07C303/32
Foreign References:
| US4199499A | 1980-04-22 | |||
| JPH07206792A | 1995-08-08 | |||
| JPH05230022A | 1993-09-07 |
Other References:
LASH T D, ET AL.: "SYNTHESIS OF PYRROLES FROM BENZYL ISOCYANOACETATE", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE., no. 02, 1 January 1994 (1994-01-01), STUTTGART, DE., pages 170 - 172, XP002919135, ISSN: 0039-7881, DOI: 10.1055/s-1994-25431
Attorney, Agent or Firm:
Hosoda, Yoshinori (Tanimachi 2-chome Chuo-ku, Osaka-shi Osaka, JP)
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