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Title:
PROCESS FOR PRODUCING MACROLIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2004/050890
Kind Code:
A1
Abstract:
It is intended to provide a novel process for producing a 12-membered macrolide compound 11107D having an antitumor activity via biological conversion. The 12-membered macrolide compound 11107B represented by the formula (I), which is a starting substance, is incubated in the presence of a strain capable of converting it into the compound 11107D represented by the formula (II) and belonging to the genus Mortierella or Streptomyces or the family of Micromonosporaceae (for example, Streptomyces sp. AB-1704 strain (FERM BP-8551)) or a cultured cell preparation thereof together with oxygen and then the target compound 11107D is harvested from the incubation medium.

Inventors:
OKUDA AKIFUMI (JP)
YAMAMOTO SATOSHI (JP)
SAKAI TAKASHI (JP)
TAKEDA SUSUMU (JP)
NAKASHIMA TAKASHI (JP)
KANEKO KATSURA (JP)
SAMESHIMA TOMOHIRO (JP)
KATO TAIRA (JP)
KAWAMURA NAOTO (JP)
Application Number:
PCT/JP2003/015170
Publication Date:
June 17, 2004
Filing Date:
November 27, 2003
Export Citation:
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Assignee:
MERCIAN CORP (JP)
EISAI CO LTD (JP)
OKUDA AKIFUMI (JP)
YAMAMOTO SATOSHI (JP)
SAKAI TAKASHI (JP)
TAKEDA SUSUMU (JP)
NAKASHIMA TAKASHI (JP)
KANEKO KATSURA (JP)
SAMESHIMA TOMOHIRO (JP)
KATO TAIRA (JP)
KAWAMURA NAOTO (JP)
International Classes:
A61K31/336; A61P35/00; C07D407/06; C12P17/16; (IPC1-7): C12P17/16; C07D407/06; C12N1/20; A61P35/00; A61K31/336
Domestic Patent References:
WO2002060890A12002-08-08
WO2003099813A12003-12-04
Foreign References:
JPH04352783A1992-12-07
Other References:
See also references of EP 1580278A4
Attorney, Agent or Firm:
Furuya, Satoshi (2-17-8 Nihonbashi-Hamach, Chuo-ku Tokyo, JP)
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