PROCESS FOR PRODUCING METHANEDIPHOSPHONIC ACID COMPOUND

Title:

PROCESS FOR PRODUCING METHANEDIPHOSPHONIC ACID COMPOUND

Document Type and Number:

WIPO Patent Application WO/1996/006100

Kind Code:

A1

Abstract:

A process for producing a 1-alkylthiomethanediphosphonic acid compound or a 1-arylthiomethanediphosphonic acid compound by the condensation reaction represented by formula (A), wherein the thiolate as the by-product is removed in the form of an insoluble salt (wherein R'1 represents C1-C6 linear or branched alkyl; R2 represents alkyl or aryl; and R1 represents a pharmacologically acceptable cation, hydrogen, or C1-C6 linear or branched alkyl). As compared with the conventional processes, this process is so improved in the yield that the product can readily be purified, thus being useful from the economic and industrial viewpoints.

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Inventors:

KAWABE NORIO (JP)
TAKANISHI KEIJIRO (JP)
UCHIRO HIROMI (JP)
TSURUTA KOUICHI (JP)
HARUTA RYUICHI (JP)

Application Number:

PCT/JP1995/001683

Publication Date:

February 29, 1996

Filing Date:

August 24, 1995

Export Citation:

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Assignee:

TORAY INDUSTRIES (JP)
KAWABE NORIO (JP)
TAKANISHI KEIJIRO (JP)
UCHIRO HIROMI (JP)
TSURUTA KOUICHI (JP)
HARUTA RYUICHI (JP)

International Classes:

C07F9/38; C07F9/40; (IPC1-7): C07F9/38; C07F9/40

Foreign References:

JPS5942395A	1984-03-08
JPH0222285A	1990-01-25
JPH05194565A	1993-08-03

Other References: