Title:
PROCESS FOR PRODUCING MONONITRATED AROMATIC ETHER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2002/048089
Kind Code:
A1
Abstract:
A process for producing a mononitrated aromatic ether compound represented by the general formula (2) (2) (wherein Z is oxygen, etc.; X is hydrogen, etc.; and R?1¿ and R?2¿ may be the same or different and each is optionally substituted alkyl, etc.), characterized by reacting an aromatic ether compound represented by the general formula (1) (1) (wherein Z, X, R?1¿, and R?2¿ are the same as defined above) with 1 to 2 mol of nitric acid per mol of the aromatic ether compound in an organic solvent in the presence of sulfuric acid.
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Inventors:
SHIRAI MASASHI (JP)
FURUYA TOSHIO (JP)
FURUYA TOSHIO (JP)
Application Number:
PCT/JP2001/010874
Publication Date:
June 20, 2002
Filing Date:
December 12, 2001
Export Citation:
Assignee:
UBE INDUSTRIES (JP)
SHIRAI MASASHI (JP)
FURUYA TOSHIO (JP)
SHIRAI MASASHI (JP)
FURUYA TOSHIO (JP)
International Classes:
C07C205/37; C07D295/092; (IPC1-7): C07C201/08; C07C205/37; C07C253/30; C07C255/54; C07D295/088; C07D317/62
Foreign References:
JPS5740447A | 1982-03-06 | |||
EP0312931A2 | 1989-04-26 | |||
EP0368008A1 | 1990-05-16 |
Other References:
WISSNER A. ET AL.: "4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors", J. MED. CHEM., vol. 43, no. 17, 2000, pages 3244 - 3256, XP002909029
Attorney, Agent or Firm:
Tsukuni, Hajime (Toranomon 1-chome Minato-ku, Tokyo, JP)
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