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Title:
PROCESS FOR PRODUCING N-FORMYLAMINO ACID AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2002/085840
Kind Code:
A1
Abstract:
A process for efficiently and industrially advantageously producing an N-formylamino acid by reacting an amino acid or its salt with formamide and/or methyl formate in the presence of a base. A process for efficiently and industrially advantageously producing N-formyl-$g(a)-aspartylphenylalanine methyl ester, which is a precursor of aspartame, by an enzymatic fusion reaction of N-formylaspartic acid with phenylalanine methyl ester wherein the concentration of N-formylaspartic acid is specified or the reaction is carried out in the presence of a trialkyl phosphate. A process for efficiently and industrially advantageously producing N-formyl-$g(a)-aspartylphenylalanine methyl ester having a high purity by adjusting the pH value of a phenylalanine methyl ester adduct of N-formyl-$g(a)-aspartylphenylalanine methyl ester.

Inventors:
KAWAHARA SHIGERU (JP)
TAKEMOTO TADASHI (JP)
FUJITA SHINJI (JP)
OHNO AYAKO (JP)
Application Number:
PCT/JP2002/003754
Publication Date:
October 31, 2002
Filing Date:
April 16, 2002
Export Citation:
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Assignee:
AJINOMOTO KK (JP)
KAWAHARA SHIGERU (JP)
TAKEMOTO TADASHI (JP)
FUJITA SHINJI (JP)
OHNO AYAKO (JP)
International Classes:
C07C231/02; C07C231/08; C07K5/072; C07K5/075; C12P13/02; C12P13/20; C12P21/02; C07C233/47; (IPC1-7): C07C231/02; C07C231/08; C07C233/47; C07K1/06; C07K1/30; C07K5/075; C12P21/02
Domestic Patent References:
WO1998016546A11998-04-23
Foreign References:
US4801742A1989-01-31
JP2000078997A2000-03-21
Other References:
See also references of EP 1380570A4
Attorney, Agent or Firm:
Ishida, Yasumasa (Bohsei Bldg. 7th Floor, 20-12, Shin-Yokohama 3-chome, Kohoku-k, Yokohama-shi Kanagawa, JP)
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