Title:
PROCESS FOR PRODUCING NATEGLINIDE CRYSTAL
Document Type and Number:
WIPO Patent Application WO/2002/032854
Kind Code:
A1
Abstract:
A process for producing nateglinide crystals which comprises reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a mixed solvent consisting of a ketone solvent and water in the presence of an alkali to obtain a reaction mixture containing nateglinide, adding an acid to the reaction mixture to make it acidic, and regulating the temperature and the ketone solvent concentration to 58 to 72°C and 8 to 22 wt.%, excluding 8 and 22 wt.%, respectively, to thereby conduct crystallization. The process is an industrially advantageous method for crystallizing nateglinide.
More Like This:
Inventors:
TAKAHASHI DAISUKE (JP)
NISHI SEIICHI (JP)
TAKAHASHI SATOJI (JP)
NISHI SEIICHI (JP)
TAKAHASHI SATOJI (JP)
Application Number:
PCT/JP2001/009069
Publication Date:
April 25, 2002
Filing Date:
October 16, 2001
Export Citation:
Assignee:
AJINOMOTO KK (JP)
TAKAHASHI DAISUKE (JP)
NISHI SEIICHI (JP)
TAKAHASHI SATOJI (JP)
TAKAHASHI DAISUKE (JP)
NISHI SEIICHI (JP)
TAKAHASHI SATOJI (JP)
International Classes:
C07C231/02; C07C231/24; C07C233/63; (IPC1-7): C07C231/24; C07C231/02; C07C233/63
Foreign References:
| EP0526171A2 | 1993-02-03 | |||
| EP0196222A2 | 1986-10-01 |
Other References:
See also references of EP 1334963A4
Attorney, Agent or Firm:
Nakamura, Minoru (Marunouchi 3-Chome Chiyoda-Ku, Tokyo, JP)
Download PDF:
Previous Patent: PROCESS FOR THE PREPARATION OF ACYLPHENYLALANINES
Next Patent: MONO- AND POLYAMIDES OF PERFLUOROALKYL-SUBSTITUTED UNSATURATED ACIDS
Next Patent: MONO- AND POLYAMIDES OF PERFLUOROALKYL-SUBSTITUTED UNSATURATED ACIDS