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Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE 1,4-BENZODIOXIN-2-CARBOXYLIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/083102
Kind Code:
A1
Abstract:
It is intended to provide a novel process for producing an optically active 1,4-benzodioxin-2-carboxylic acid derivative, which is usable as an intermediate in synthesizing an optically active drug, via biological conversion. Namely, a 6-(2-oxopropyl)-1,4-benzodioxin-2-carboxylic acid derivative employed as the starting material is incubated in the presence of cultured cells or a cultured cell preparation of a microorganism capable of converting the starting material into an optically active 6-(2-hydroxypropyl)-1,4-benzodioxin-2-carboxylic acid derivative. Then the target optically active 6-(2-hydroxypropyl)-1,4-benzodioxin-2-carboxylic acid derivative is collected from the liquid incubation mixture thus obtained.

Inventors:
TOYODA ASAKO (JP)
YOSHIDA MASASHI (JP)
KANEKO KATSURA (JP)
Application Number:
PCT/JP2005/002541
Publication Date:
September 09, 2005
Filing Date:
February 18, 2005
Export Citation:
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Assignee:
MERCIAN CORP (JP)
TOYODA ASAKO (JP)
YOSHIDA MASASHI (JP)
KANEKO KATSURA (JP)
International Classes:
C07D319/20; C12N1/14; C12N1/16; C12P17/06; (IPC1-7): C12P17/06; C07D319/20; C12N1/14; C12N1/16
Domestic Patent References:
WO2000006562A12000-02-10
WO1996035685A11996-11-14
Other References:
NEUMANN S, ET AL: "On a non-pyridine nucleotide-dependent 2-oxo-acid reductase of broad substrate specificity from two Proteus species", FEBS LETTERS, vol. 167, no. 1, 1984, pages 29 - 32, XP002989815
TODA F. ET AL: "New reduction method of alpha-diketones, oxo amides, and quinones with Zn-EtOH in the presence of a salt", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, ORGANIC AND BIO-ORGANIC CHEMISTRY, vol. 8, 1989, pages 1555 - 1556, XP002989885
Attorney, Agent or Firm:
SIKs & Co. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo 31, JP)
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