Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-HALO-1,2-PROPANEDIOL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2003/070676
Kind Code:
A1
Abstract:
A process for easily producing from an inexpensive material an optically active 3-halo-1,2-propanediol derivative useful as an intermediate for medicines. The process comprises reacting 2-chloroallyl alcohol, which is easily available at low cost, with a hypohalogenous acid salt or a halogen to convert the alcohol into a halohydroxyacetone derivative and subsequently asymmetrically hydrogenating the halohydroxyacetone derivative with hydrogen and an asymmetric hydrogenation catalyst prepared from a transition metal and an optically active phosphine ligand to thereby produce an optically active 3-halo-1,2-propanediol derivative.
Inventors:
Taoka, Naoaki c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Sugawara, Masanobu c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Yasohara, Yoshihiko c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Sugawara, Masanobu c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Yasohara, Yoshihiko c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Application Number:
PCT/JP2003/001962
Publication Date:
August 28, 2003
Filing Date:
February 24, 2003
Export Citation:
Assignee:
KANEKA CORPORATION (2-4 Nakanoshima 3-chome, Kita-ku Osaka-shi, Osaka, 530-8288, JP)
Taoka, Naoaki c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Sugawara, Masanobu c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Yasohara, Yoshihiko c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Taoka, Naoaki c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Sugawara, Masanobu c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Yasohara, Yoshihiko c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
International Classes:
C07B53/00; C07B61/00; C07C29/145; C07C31/42; C07C45/00; C07C45/30; C07C45/81; C07C49/173; C07D319/12; (IPC1-7): C07C45/30; C07C49/173; C07C29/145; C07C31/42; C07D319/12; C07B53/00; C07B61/00
Attorney, Agent or Firm:
Yasutomi, Yasuo (Chuo BLDG, 4-20 Nishinakajima 5-chome, Yodogawa-k, Osaka-shi Osaka, 532-0011, JP)
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