PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-HYDROXYPROPIONIC ESTER DERIVATIVE

Title:

PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-HYDROXYPROPIONIC ESTER DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2004/052829

Kind Code:

A1

Abstract:

A process for easily producing from an inexpensive material an optically active 3-hydroxypropionic ester derivative useful as an intermediate for medicines. The process, which is for producing an optically active 3-hydroxypropionic ester derivative, comprises reacting an inexpensively available acetic ester derivative with a base and a formic ester to convert the acetic ester derivative into a 2-formylacetic ester derivative and stereoselectively reducing the formyl group of the derivative with an enzyme source having the ability to stereoselectively reduce the formyl group of the derivative.

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Inventors:

TAOKA NAOAKI (JP)
MORIYAMA DAISUKE (JP)
MORI KOHEI (JP)
OISHI TAKAHIRO (JP)

Application Number:

PCT/JP2003/015644

Publication Date:

June 24, 2004

Filing Date:

December 08, 2003

Export Citation:

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Assignee:

KANEKA CORP (JP)
TAOKA NAOAKI (JP)
MORIYAMA DAISUKE (JP)
MORI KOHEI (JP)
OISHI TAKAHIRO (JP)

International Classes:

C07C67/313; C07D317/60; C12P7/62; C12P17/04; C12P41/00; (IPC1-7): C07C67/36; C07C69/716; C07D317/60; C12P41/00

Foreign References:

EP0212859A2

1987-03-04

Other References: