PROCESS FOR PRODUCING OPTICALLY ACTIVE 4-CHLORO-3-HYDROXYBUTANAL COMPOUND

Title:

PROCESS FOR PRODUCING OPTICALLY ACTIVE 4-CHLORO-3-HYDROXYBUTANAL COMPOUND

Document Type and Number:

WIPO Patent Application WO/2012/053564

Kind Code:

A1

Abstract:

Provided is a novel process for producing an optically active 4-chloro-3-hydroxybutanal compound. Specifically provided is a process for producing an optically active 4-chloro-3-hydroxybutanal compound (2), which comprises a step of reacting chloroacetaldehyde with an aldehyde compound (1) in the presence of an optically active pyrrolidine compound (5). (In the formula, each symbol is as defined in the description.)

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Inventors:

HAYASHI YUJIRO (JP)

Application Number:

PCT/JP2011/074072

Publication Date:

April 26, 2012

Filing Date:

October 19, 2011

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Assignee:

UNIV TOKYO SCI EDUC FOUND (JP)
SUMITOMO CHEMICAL CO (JP)
HAYASHI YUJIRO (JP)

International Classes:

C07C45/72; C07C41/50; C07C43/315; C07C47/195; C07C67/343; C07C69/732; C07D301/26; C07D303/12; C07D303/16; C07B53/00

Domestic Patent References:

WO2005098012A1

2005-10-20

Foreign References:

JP2010013392A	2010-01-21
JP2008007457A	2008-01-17

Other References:

HAYASHI Y.: "Recent Progress in the Asymmetric Organocatalysis", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN, vol. 63, no. 5, 2005, pages 464 - 477, XP055087202
BARBAS C.F. ET AL.: "DEOXYRIBOSE-5-PHOSPHATE ALDOLASE AS A SYNTHETIC CATALYST", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 112, no. 5, 1990, pages 2013 - 2014, XP002049679
HAYASHI Y. ET AL.: "One-Pot Synthesis of Chiral ALPHA-Substituted BETA,GAMA-Epoxy Aldehyde Derivatives through an Asymmetric Aldol Reaction of Chloroacetaldehyde", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 50, no. 12, 17 February 2011 (2011-02-17), pages 2804 - 2807, XP055087257
See also references of EP 2631227A4

Attorney, Agent or Firm:

TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)

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