Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE 6-SULFONYLOXYMETHYL-1,3-DIOXAN-4-YLACETIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2004/011420
Kind Code:
A1
Abstract:
A process by which an optically active 6-sulfonyloxymethyl-1,3-dioxan-4-ylacetic acid derivative useful as an intermediate for medicines can be easily produced through short steps from an inexpensive, easily available material. The process comprises sulfonylating an easily available, optically active 5,6-dihydroxy-3-oxohexanoic acid derivative in the presence of a base to produce an optically active 5-hydroxy-3-oxo-6-sulfonyloxyhexanoic acid derivative, subsequently reducing the derivative to produce an optically active 3,5-dihydroxy-6-sulfonyoxyhexanoic acid derivative, and then acetalizing it in the presence of an acid catalyst to produce an optically active 6-sulfonyloxymethyl-1,3-dioxan-4-ylacetic acid derivative.
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Inventors:
KISHIMOTO NARUMI (JP)
NISHIYAMA AKIRA (JP)
NAGASHIMA NOBUO (JP)
INOUE KENJI (JP)
NISHIYAMA AKIRA (JP)
NAGASHIMA NOBUO (JP)
INOUE KENJI (JP)
Application Number:
PCT/JP2003/008572
Publication Date:
February 05, 2004
Filing Date:
July 07, 2003
Export Citation:
Assignee:
KANEKA CORP (JP)
KISHIMOTO NARUMI (JP)
NISHIYAMA AKIRA (JP)
NAGASHIMA NOBUO (JP)
INOUE KENJI (JP)
KISHIMOTO NARUMI (JP)
NISHIYAMA AKIRA (JP)
NAGASHIMA NOBUO (JP)
INOUE KENJI (JP)
International Classes:
C07B53/00; C07B61/00; C07C303/24; C07C303/28; C07C303/30; C07C309/73; C07D319/06; C07C305/06; (IPC1-7): C07C309/73; C07B53/00; C07C303/28; C07C303/30; C07D319/06
Foreign References:
| JPH05308977A | 1993-11-22 | |||
| US5399722A | 1995-03-21 | |||
| EP0385733A2 | 1990-09-05 |
Attorney, Agent or Firm:
Yasutomi, Yasuo (4-20 Nishinakajima 5-chome, Yodogawa-k, Osaka-shi Osaka, JP)
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