Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE BENZYLSUCCINIC ACID AND INTERMEDIATE THEREFOR
Document Type and Number:
WIPO Patent Application WO/1998/032727
Kind Code:
A1
Abstract:
A process for producing the optically active benzylsuccinic acid represented by formula (III) (wherein the carbon atom indicated by (S) has the S configuration), which is useful as a starting material for the benzylsuccinic acid derivative represented by formula (I) and salts thereof which are useful as a diabetic remedy, from a mixture of corresponding optical isomers through optical resolution using as an optical resolving agent an organic amine selected among (R)-1-(1-naphthyl)ethylamine, (R)-$g(a)-methylbenzylamine, (S)-1-phenyl-2-(p-tolyl)ethylamine, and quinine; and salts of the optically active benzylsuccinic acid, useful in the method of optical resolution, with an organic amine selected among (R)-1-(1-naphthyl)ethylamine, (R)-$g(a)-methylbenzylamine, (S)-1-phenyl-2-(p-tolyl)ethylamine, and quinine. The optically active benzylsuccinic acid having a high optical purity and a high chemical purity can be efficiently obtained by the method of optical resolution.
Inventors:
KAMIJO TETSUHIDE (JP)
YAMAGUCHI TOSHIAKI (JP)
YANAGI TAKASHI (JP)
YAMAGUCHI TOSHIAKI (JP)
YANAGI TAKASHI (JP)
Application Number:
PCT/JP1998/000230
Publication Date:
July 30, 1998
Filing Date:
January 22, 1998
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
KAMIJO TETSUHIDE (JP)
YAMAGUCHI TOSHIAKI (JP)
YANAGI TAKASHI (JP)
KAMIJO TETSUHIDE (JP)
YAMAGUCHI TOSHIAKI (JP)
YANAGI TAKASHI (JP)
International Classes:
C07C51/487; C07D209/44; (IPC1-7): C07C57/34; C07B57/00; C07C51/42
Foreign References:
| JPS5663940A | 1981-05-30 | |||
| JPH0578276A | 1993-03-30 | |||
| US4983765A | 1991-01-08 | |||
| JPH0276838A | 1990-03-16 | |||
| JPH07149688A | 1995-06-13 | |||
| JPS59170036A | 1984-09-26 | |||
| JPS5890573A | 1983-05-30 | |||
| JPS55118456A | 1980-09-11 | |||
| JPS61293949A | 1986-12-24 |
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