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Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID
Document Type and Number:
WIPO Patent Application WO/2010/067824
Kind Code:
A1
Abstract:
A process for industrially producing an intermediate for a compound that shows an inhibitory action on an activated blood coagulation factor X and that is useful as a preventive and/or therapeutic agent for thrombotic diseases has been desired. Provided is a process for producing (R)-α-phenylethylamine (S)-3-cyclohexene-1-carboxylate, the process being characterized by reacting 3-cyclohexene-1-carboxylic acid with (R)-α-phenylethylamine using, as a solvent, a water/acetone mixed solvent or a water/ethyl acetate mixed solvent.

Inventors:
SATO, Koji (())
佐藤 耕司 (())
Application Number:
JP2009/070613
Publication Date:
June 17, 2010
Filing Date:
December 09, 2009
Export Citation:
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Assignee:
DAIICHI SANKYO COMPANY,LIMITED (3-5-1, Nihonbashi HonchoChuo-k, Tokyo 26, 〒1038426, JP)
第一三共株式会社 (〒26 東京都中央区日本橋本町三丁目5番1号 Tokyo, 〒1038426, JP)
SATO, Koji (())
International Classes:
C07C51/41; C07B57/00; C07C51/02; C07C51/09; C07C51/43; C07C51/493; C07C61/22
Domestic Patent References:
WO2003000680A12003-01-03
WO2003000657A12003-01-03
WO2003000680A12003-01-03
WO2003016302A12003-02-27
WO2004058715A12004-07-15
Foreign References:
JP2001151724A2001-06-05
Other References:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 100, no. 16, 1978, pages 5199 - 5203
TETRAHEDRON ASYMMETRY, vol. 15, 2004, pages 2057 - 2060
TETRAHEDRON LETTERS, vol. 32, no. 13, 1991, pages 1613 - 1616
JOURNAL OF ORGANIC CHEMISTRY, vol. 31, 1966, pages 240 - 243
CSJ: THE CHEMICAL SOCIETY OF JAPAN: "Kogaku Iseitai no Bunri 'Kikan Kagaku Sosetsu No.6", JAPAN SCIENTIFIC SOCIETIES PRESS, pages: 45 - 54
HAROLD M. SCHWARTZ ET AL., J. AM. CHEM. SOC., vol. 100, 1978, pages 5199 - 5203
CIHANGIR TANYELI ET AL., TETRAHEDRON: ASYMMETRY, vol. 15, 2004, pages 2057 - 2060
BARRY M. TROST ET AL., TETRAHEDRON LETT., vol. 32, 1991, pages 1613 - 1616
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (LIMITED 1-16-13,Kitakasai, Edogawa-k, Tokyo 81, 〒1340081, JP)
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