Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE CHROMENE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1999/042459
Kind Code:
A1
Abstract:
A process for producing a compound represented by formula (II) (wherein R?1¿, R?2¿, R?3¿, and R?4¿ each independently represents hydrogen, alkyl, alkoxy, etc.; R?5¿ represents alkyl or alkoxyalkyl; A represents O or S; Ar represents aryl, etc.; * indicates the position of an asymmetric carbon atom and that the compound is the (R) or (S) isomer; and Q represents an optically active reagent), characterized by isolating the target compound as crystals from a solution or suspension containing a compound represented by formula (II) (wherein * indicates the position of an asymmetric carbon atom and that the compound is the (R) or (S) isomer or is a mixture of both, and the other symbols have the same meanings as the above).
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Inventors:
KONOIKE TOSHIRO (JP)
YORIFUJI TADAHIKO (JP)
SHINOMOTO SHOJI (JP)
IDE YUTAKA (JP)
OHYA TAKASHI (JP)
MATSUMURA KEN-ICHI (JP)
YORIFUJI TADAHIKO (JP)
SHINOMOTO SHOJI (JP)
IDE YUTAKA (JP)
OHYA TAKASHI (JP)
MATSUMURA KEN-ICHI (JP)
Application Number:
PCT/JP1999/000650
Publication Date:
August 26, 1999
Filing Date:
February 16, 1999
Export Citation:
Assignee:
SHIONOGI & CO (JP)
KONOIKE TOSHIRO (JP)
YORIFUJI TADAHIKO (JP)
SHINOMOTO SHOJI (JP)
IDE YUTAKA (JP)
OHYA TAKASHI (JP)
MATSUMURA KEN ICHI (JP)
KONOIKE TOSHIRO (JP)
YORIFUJI TADAHIKO (JP)
SHINOMOTO SHOJI (JP)
IDE YUTAKA (JP)
OHYA TAKASHI (JP)
MATSUMURA KEN ICHI (JP)
International Classes:
C07D311/30; C07D407/04; (IPC1-7): C07D311/30; A61K31/35; A61K31/36; A61K31/38; C07B57/00; C07D335/06; C07D407/04; C07D409/04
Domestic Patent References:
| WO1998008836A1 | 1998-03-05 |
Foreign References:
| JPS60149581A | 1985-08-07 |
Other References:
CHAWLA H P S, GROVER P K, ANAND N: "SYNTHESIS OF CIS-(3A,9A)-CIS-(9A,9)-7-METHYL-9-PHENYL-1- OXOTETRAHYDROFURANO¬3,4-B¾BENZO-PYRAN", INDIAN JOURNAL OF CHEMISTRY, JODHPUR, IN, vol. 08, 1 May 1970 (1970-05-01), IN, pages 472/473, XP002929201
SAENGCHANTARA S T, WALLACE T W: "CONJUGATE ADDITION OF CUPRATE REAGENTS TO CHROMONES: A ROUTE TO 2-SUBSTITUTED CHROMAN-4-ONES", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 46, no. 08, 1 January 1990 (1990-01-01), AMSTERDAM, NL, pages 3029 - 3036, XP002929202, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)88394-0
See also references of EP 1057824A4
SAENGCHANTARA S T, WALLACE T W: "CONJUGATE ADDITION OF CUPRATE REAGENTS TO CHROMONES: A ROUTE TO 2-SUBSTITUTED CHROMAN-4-ONES", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 46, no. 08, 1 January 1990 (1990-01-01), AMSTERDAM, NL, pages 3029 - 3036, XP002929202, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)88394-0
See also references of EP 1057824A4
Attorney, Agent or Firm:
Yamauchi, Hideaki (Ltd. Patent Dept. 12-4 Sagisu 5-chome Fukushima-ku, Osaka-shi Osaka, JP)
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