Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE ESTER
Document Type and Number:
WIPO Patent Application WO/2007/023906
Kind Code:
A1
Abstract:
A process for producing an optically active 2-hydroxybutyric ester (1), characterized by
reacting an optically active 2,3-epoxybutyric ester (2) with a thiol compound in
the presence of scandium trifluoromethanesulfonate or ytterbium trifluoromethanesulfonate to
obtain a compound (3) and subjecting it to a desulfurization reaction. (2) →
(3) → (1) [In the formulae, R represents C1-6 alkyl or C7-8
aralkyl; R1 represents C1-12 alkyl or phenyl; and * indicates
absolute S- or R-configuration.] The process enables an optically active 2-hydroxybutyric
ester having a high optical purity to be obtained in a high yield.
Inventors:
ARAKI, Takaaki (2-17-43-307, Noguchi-cho Higashimurayama-sh, Tokyo 22, 1890022, JP)
荒木 崇彰 (〒22 東京都東村山市野口町２－１７－４３－３０７ Tokyo, 1890022, JP)
YAMAZAKI, Yukiyoshi (1-12-13-406, Hon-cho Higashimurayama-sh, Tokyo 14, 1890014, JP)
荒木 崇彰 (〒22 東京都東村山市野口町２－１７－４３－３０７ Tokyo, 1890022, JP)
YAMAZAKI, Yukiyoshi (1-12-13-406, Hon-cho Higashimurayama-sh, Tokyo 14, 1890014, JP)
Application Number:
JP2006/316624
Publication Date:
March 01, 2007
Filing Date:
August 24, 2006
Export Citation:
Assignee:
KOWA CO., LTD. (6-29, Nishiki 3-chome Naka-ku, Nagoya-sh, Aichi 25, 4608625, JP)
興和株式会社 (〒25 愛知県名古屋市中区錦三丁目６番２９号 Aichi, 4608625, JP)
ARAKI, Takaaki (2-17-43-307, Noguchi-cho Higashimurayama-sh, Tokyo 22, 1890022, JP)
荒木 崇彰 (〒22 東京都東村山市野口町２－１７－４３－３０７ Tokyo, 1890022, JP)
興和株式会社 (〒25 愛知県名古屋市中区錦三丁目６番２９号 Aichi, 4608625, JP)
ARAKI, Takaaki (2-17-43-307, Noguchi-cho Higashimurayama-sh, Tokyo 22, 1890022, JP)
荒木 崇彰 (〒22 東京都東村山市野口町２－１７－４３－３０７ Tokyo, 1890022, JP)
International Classes:
C07C67/317; C07C19/14; C07C69/675; C07C323/52; C07B53/00
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (Kyodo Bldg, 3-6 Nihonbashiningyocho, 1-chom, Chuo-ku Tokyo 13, 1030013, JP)
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