Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE FLUOROBENZYL ALCOHOL
Document Type and Number:
WIPO Patent Application WO/2007/043407
Kind Code:
A1
Abstract:
A fluorobenzaldehyde is reacted with an alkyl Grignard reagent to convert them into a magnesium alkoxide of a racemic fluorobenzyl alcohol. Subsequently, the magnesium alkoxide is reacted with phthalic anhydride to obtain a half ester of phthalic acid with the racemic fluorobenzyl alcohol. The half ester is optically resolved with optically active 1-phenylethylamine. Thereafter, the ester group is hydrolyzed. Thus, an optically active fluorobenzyl alcohol is produced.
Inventors:
ISHII AKIHIRO
UEDA KOJI
YASUMOTO MANABU
UEDA KOJI
YASUMOTO MANABU
Application Number:
PCT/JP2006/319862
Publication Date:
April 19, 2007
Filing Date:
October 04, 2006
Export Citation:
Assignee:
CENTRAL GLASS CO LTD (JP)
ISHII AKIHIRO
UEDA KOJI
YASUMOTO MANABU
ISHII AKIHIRO
UEDA KOJI
YASUMOTO MANABU
International Classes:
C07C29/09; C07C33/46; C07C67/08; C07C69/80; C07B57/00
Foreign References:
| JPH09124527A | 1997-05-13 |
Other References:
ALLEN A.D. ET AL: "Solvolysis of 1-Arylethyl Tosylates. Kinetic and Stereochemical Tests for Solvent Participation", JOURNAL OF THE AMERICAN CHEMISTRY SOCIETY, vol. 107, no. 15, 1985, pages 4513 - 4519, XP003011739
PICKARD S.T. ET AL: "Optically Active Amines. 34. Application of the Benzene Chirality Rule to Ring-substituted Phenylcarbinamines and Carbinols", JOURNAL OF THE AMERICAN CHEMISTRY SOCIETY, vol. 112, no. 15, 1990, pages 5741 - 5747, XP003011740
See also references of EP 1935866A4
PICKARD S.T. ET AL: "Optically Active Amines. 34. Application of the Benzene Chirality Rule to Ring-substituted Phenylcarbinamines and Carbinols", JOURNAL OF THE AMERICAN CHEMISTRY SOCIETY, vol. 112, no. 15, 1990, pages 5741 - 5747, XP003011740
See also references of EP 1935866A4
Attorney, Agent or Firm:
HASHIMOTO, Takeshi et al. (Ekisaikai Bldg. 1-29, Akashi-cho, Chuo-k, Tokyo 44, JP)
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