PROCESS FOR PRODUCING OPTICALLY ACTIVE HALOPROPANEDIOL DERIVATIVE

Title:

PROCESS FOR PRODUCING OPTICALLY ACTIVE HALOPROPANEDIOL DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2003/018523

Kind Code:

A1

Abstract:

A process for easily producing from an inexpensive material an optically active halopropanediol derivative which is useful as an intermediate for medicines. An inexpensively available propargyl alcohol derivative is reacted with a hypohalogenous acid to convert the derivative into a di− or trihalohydroxyacetone derivative. This derivative is hydrogenated in the presence of a transition metal catalyst to produce a monohalohydroxyacetone derivative. Furthermore, a source of an enzyme having the ability to stereoselectively reduce the carbonyl groups of halohydroxyacetone derivatives is used to stereoselectively reduce the halohydroxyacetone derivative to produce an optically active halopropanediol derivative.

Inventors:

Taoka, Naoaki c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Nishiyama, Tozo c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Kisaki, Noriyuki c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Yasohara, Yoshihiko c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)

Application Number:

PCT/JP2002/008624

Publication Date:

March 06, 2003

Filing Date:

August 27, 2002

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Assignee:

KANEKA CORPORATION (2-4 Nakanoshima 3-chome, Kita-ku Osaka-shi, Osaka, 530-8288, JP)
Taoka, Naoaki c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Nishiyama, Tozo c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Kisaki, Noriyuki c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)
Yasohara, Yoshihiko c/o KANEKA CORPORATION Takasago Plant (1-8 Takasagochomiyamaech, Takasago-shi Hyogo, 676-0027, JP)

International Classes:

C07C45/30; C07C45/65; C07C49/173; C07D319/12; C07K14/705; C12P7/18; (IPC1-7): C07C49/173; C07C45/26; C07C45/45; C07C45/65; C07D319/12; C12P7/18

Attorney, Agent or Firm:

Yasutomi, Yasuo (Chuo BLDG, 4-20 Nishinakajima 5-chome, Yodogawa-k, Osaka-shi Osaka, 532-0011, JP)

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