Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE ISOMERS OF TRICYCLIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/1998/037042
Kind Code:
A1
Abstract:
Optically active isomers of tricyclic compounds, typically cyclopenta[b]benzofuran derivatives represented by general formula (II) wherein R�1?, R�2?, Y and Z each represents hydrogen, halogeno, alkyl, or aryl; W represents oxygen, sulfur, nitrogen, or carbon; and n is 0 to 4, and directly produced by adding an optionally active alcohol, amine, or/and metal salt thereof. This process is highly useful because it needs neither a complicated operation for optical resolution nor an enzymatic reaction requiring a large amount of a solvent and a long reaction time and less apt to attain reproducibility, and because it is applicable to both experimental and industrial processes.
Inventors:
NISHIYAMA HISAO (JP)
NAGASE HIROSHI (JP)
WAKITA HISANORI (JP)
NAGASE HIROSHI (JP)
WAKITA HISANORI (JP)
Application Number:
PCT/JP1998/000694
Publication Date:
August 27, 1998
Filing Date:
February 19, 1998
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
NISHIYAMA HISAO (JP)
NAGASE HIROSHI (JP)
WAKITA HISANORI (JP)
NISHIYAMA HISAO (JP)
NAGASE HIROSHI (JP)
WAKITA HISANORI (JP)
International Classes:
C07D307/935; (IPC1-7): C07C13/54; C07C25/22; C07D209/80; C07D307/93; C07D333/54; C07D333/78
Foreign References:
| JPH01279878A | 1989-11-10 | |||
| JPH02200681A | 1990-08-08 |
Other References:
NISHIYAMA H., ET AL.: "METAL-HALOGEN EXCHANGE BETWEEN POLYBROMOANISOLES AND ALIPHATIC GRIGNARD REAGENTS: A SYNTHESIS OF CYCLOPENTAÚB¾BENZOFURANS.", JOURNAL OF ALLOYS AND COMPOUNDS., ELSEVIER SEQUOIA, LAUSANNE., CH, vol. 57., 1 January 1992 (1992-01-01), CH, pages 407 - 410., XP002912295, ISSN: 0925-8388
HOSOKAWA T., ET AL.: "OXIDATIVE CYCLIZATION OF 2-ALLYLPHENOLS BY PALLADIUM(II) ACETATE. CHANGES IN PRODUCT DISTRIBUTION.", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 43., no. 14., 1 January 1978 (1978-01-01), US, pages 2752 - 2757., XP002912296, ISSN: 0022-3263, DOI: 10.1021/jo00408a004
See also references of EP 0915073A4
HOSOKAWA T., ET AL.: "OXIDATIVE CYCLIZATION OF 2-ALLYLPHENOLS BY PALLADIUM(II) ACETATE. CHANGES IN PRODUCT DISTRIBUTION.", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 43., no. 14., 1 January 1978 (1978-01-01), US, pages 2752 - 2757., XP002912296, ISSN: 0022-3263, DOI: 10.1021/jo00408a004
See also references of EP 0915073A4
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