Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE TRANS-2-BROMOINDAN-1-OL
Document Type and Number:
WIPO Patent Application WO/1997/007234
Kind Code:
A1
Abstract:
A process comprising the step of treating trans-(+/-)-2-bromoindan-1-o1 in an organic solvent with a lipase originating in a yeast or a recombinant of the same; the step of selectively esterifying either the (+)-alcohol or the (-)-alcohol; and the step of separating the ester from the alcohol. Trans-2-Bromoindan-1-o1 of a high optical activity, which is useful as an intermediate of drugs, and its ester derivatives of a high optical activity are industrially and economically produced in high yields.
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Inventors:
IGARASHI YOSHIO (JP)
OTSUTOMO SHINYA (JP)
SHIMOYAMADA MAKOTO (JP)
HARADA MASAYUKI (JP)
NAKANO SHIGERU (JP)
OTSUTOMO SHINYA (JP)
SHIMOYAMADA MAKOTO (JP)
HARADA MASAYUKI (JP)
NAKANO SHIGERU (JP)
Application Number:
PCT/JP1996/002233
Publication Date:
February 27, 1997
Filing Date:
August 08, 1996
Export Citation:
Assignee:
ICHIKAWA GOSEI KAGAKU KK (JP)
IGARASHI YOSHIO (JP)
OTSUTOMO SHINYA (JP)
SHIMOYAMADA MAKOTO (JP)
HARADA MASAYUKI (JP)
NAKANO SHIGERU (JP)
IGARASHI YOSHIO (JP)
OTSUTOMO SHINYA (JP)
SHIMOYAMADA MAKOTO (JP)
HARADA MASAYUKI (JP)
NAKANO SHIGERU (JP)
International Classes:
C07C17/35; C07C23/34; C12P7/22; C12P41/00; C12R1/72; (IPC1-7): C12P41/00
Other References:
TETRAHEDRON: ASYMMETRY, Vol. 7, No. 6, (1996), D.R. BOYD et al., "Stereoselective Dioxygenase-Catalysed Benzylic Hydroxylation at Prochiral Methylene Groups in the Chemoenzymatic Synthesis of Enantiopure Vicinal Aminoindanols", p. 1559-1562.
TETRAHEDRON LETTERS, Vol. 22, No. 27, (1981), K. KAWAI et al., "Microbially Mediated Enantioselective Hydrolysis of Racemic Acetates", p. 2527-2530.
J. ORG. CHEM., Vol. 49, No. 4, (1984), M. KASAI et al., "Enantioselective Ester Hydrolyses Employing Rhizopus Nigricans. A Method of Preparing and Assigning the Absolute Stereochemistry of Cyclic Alcohols", p. 675-679.
TETRAHEDRON LETTERS, Vol. 22, No. 27, (1981), K. KAWAI et al., "Microbially Mediated Enantioselective Hydrolysis of Racemic Acetates", p. 2527-2530.
J. ORG. CHEM., Vol. 49, No. 4, (1984), M. KASAI et al., "Enantioselective Ester Hydrolyses Employing Rhizopus Nigricans. A Method of Preparing and Assigning the Absolute Stereochemistry of Cyclic Alcohols", p. 675-679.
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