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Title:
PROCESS FOR PRODUCING ORGANOLITHIUM COMPOUND AND PROCESS FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/073714
Kind Code:
A1
Abstract:
A process for producing an organolithium compound which comprises a step in which an aromatic compound or a halogenated unsaturated aliphatic compound is reacted with a lithiating agent at a temperature of -40ºC to 40ºC in the presence of either a coordinating compound having, per molecule, three or more elements which have coordinating ability and at least one of which is a nitrogen element or a coordinating compound which has, per molecule, three or more oxygen elements having coordinating ability and in which at least one of the groups having the oxygen elements having coordinating ability is a tertiary alkoxy group.

Inventors:
INOUE, Hiroki (Nippon Soda Co. Ltd., 300, Mukainohonmachi, Takaoka-sh, Toyama 07, 〒9338507, JP)
Application Number:
JP2009/007286
Publication Date:
July 01, 2010
Filing Date:
December 25, 2009
Export Citation:
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Assignee:
Nippon Soda Co., Ltd. (2-1 Ohtemachi 2-chome, Chiyoda-ku Tokyo, 65, 〒1008165, JP)
日本曹達株式会社 (〒65 東京都千代田区大手町二丁目2番1号  Tokyo, 〒1008165, JP)
International Classes:
C07F1/02; C07C211/14; C07C217/08; C07F5/02
Foreign References:
DE10243618A12003-06-05
JP2000229981A2000-08-22
JP2006241065A2006-09-14
JP2007262151A2007-10-11
JP2003286279A2003-10-10
JP2000229981A2000-08-22
JP2006241065A2006-09-14
JP2008195639A2008-08-28
Other References:
INUE, I. ET AL.: "Asymmetric 1,2-addition of organolithiums to aldimines catalyzed by chiral ligand", TETRAHEDRON, vol. 50, no. 15, 1994, pages 4429 - 38, XP008139534
JONES, C.A. ET AL.: "Asymmetric addition of organolithium reagents to imines favoring (S)-amines", TETRAHEDRON LETTERS, vol. 36, no. 43, 1995, pages 7885 - 8, XP005254800
See also references of EP 2371831A4
"Lecture of Graduated School: Organic Chemistry I, Molecular Structure and Reaction/Organometallic Chemistry", pages: 320
SCOTT, J.P., BERWER, S.E., DAVIES, A.J., BRANDS, K.M.J.: "Preparation, thermal stability and carbonyl addition reactions of 2,5-difluorophenyl lithium and 2, 5-difluorophenyl grignard", SYNLETT, 2004, pages 1646
ZBINDEN, K.G., BANNER, D.W., HILPERT, K., HIMBER, J., LAVE, T., RIEDERER, M.A., STAHL, M., TSCHOPP, T.B., OBST-SANDER, U., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 2006, pages 5357
"Process Development and Pilot Plant Synthesis of Methyl 2-Bromo-6-chlorobenzoate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 9, 2005, pages 764 - 767, XP002515823, DOI: doi:10.1021/op0501444
LEROUX, F., HUTSCHENREUTER, T.U., CHARRIERE, C., SCOPELLITI, R., HARTMANN, R.W., HELVETICA CHIMICA ACTA, vol. 86, 2003, pages 2671
Attorney, Agent or Firm:
SHIGA, Masatake et al. (1-9-2, Marunouchi Chiyoda-k, Tokyo 20, 〒1006620, JP)
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