Title:
PROCESS FOR PRODUCING RAPAMYCIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2011/051960
Kind Code:
A3
Abstract:
The invention relates to processes for the preparation of compound of CCI-779 having the Formula (I), which is useful as an antineoplastic agent. The invention further relates to certain novel intermediates useful in the preparation of compound of CCI-779 and processes for their preparation. The invention also relates to pharmaceutical compositions that include the compound of CCI-779, prepared according to the processes disclosed herein.
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Inventors:
DAVE MAYANK GHANSHYAMBHAI (IN)
PANDEY BIPIN (IN)
PANDEY BIPIN (IN)
Application Number:
PCT/IN2010/000646
Publication Date:
June 23, 2011
Filing Date:
September 24, 2010
Export Citation:
Assignee:
CADILA HEALTHCARE LTD (IN)
DAVE MAYANK GHANSHYAMBHAI (IN)
PANDEY BIPIN (IN)
DAVE MAYANK GHANSHYAMBHAI (IN)
PANDEY BIPIN (IN)
International Classes:
C07D498/18; A61K31/435; A61P37/06; C07D319/06; C07D319/08
Domestic Patent References:
| WO2006095185A1 | 2006-09-14 | |||
| WO2005016935A2 | 2005-02-24 | |||
| WO2005035528A2 | 2005-04-21 |
Foreign References:
| US5362718A | 1994-11-08 |
Other References:
SORBERA L A ET AL: "CCI-779: Oncolytic mTOR inhibitor", DRUGS OF THE FUTURE 2002 ES LNKD- DOI:10.1358/DOF.2002.027.01.654066, vol. 27, no. 1, 2002, pages 7 - 13, XP002631962, ISSN: 0377-8282
GU JIANXIN ET AL: "lipase-catalyzed regioselective esterification of rapamycin: synthesis of temsirolimus (CCI-779).", ORGANIC LETTERS 1 SEP 2005 LNKD- PUBMED:16119938, vol. 7, no. 18, 1 September 2005 (2005-09-01), pages 3945 - 3948, XP002631963, ISSN: 1523-7060
CHEN YANQIU ET AL: "Conformational changes of rapamycin and analogs upon complexing with FKBP associated with activity: An application of second derivative CD spectroscopy", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 116, no. 6, 1994, pages 2683 - 2684, XP002631964, ISSN: 0002-7863
GU JIANXIN ET AL: "lipase-catalyzed regioselective esterification of rapamycin: synthesis of temsirolimus (CCI-779).", ORGANIC LETTERS 1 SEP 2005 LNKD- PUBMED:16119938, vol. 7, no. 18, 1 September 2005 (2005-09-01), pages 3945 - 3948, XP002631963, ISSN: 1523-7060
CHEN YANQIU ET AL: "Conformational changes of rapamycin and analogs upon complexing with FKBP associated with activity: An application of second derivative CD spectroscopy", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 116, no. 6, 1994, pages 2683 - 2684, XP002631964, ISSN: 0002-7863
Attorney, Agent or Firm:
SUBRAMANIAM, Hariharan (Nataraj & AssociatesE-556, Greater Kailash-II, New Delhi 8, IN)
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