Title:
PROCESS FOR PRODUCING SOLID PARTICLES
Document Type and Number:
WIPO Patent Application WO/2014/050910
Kind Code:
A1
Abstract:
A process for producing crystals of a poorly water-soluble medicinal compound, characterized by mixing a solution of the poorly water-soluble medicinal compound in a good solvent with a nanobubbles-containing water or a nanobubbles-containing aqueous solution to precipitate crystals of the poorly water-soluble medicinal compound. The crystals of a poorly water-soluble medicinal compound which are obtained by the process are in the form of fine particles having a uniform particle diameter distribution, and exhibit excellent absorbability and persistence.
More Like This:
Inventors:
MURATA NAOYUKI (JP)
YANAI SHIGEO (JP)
YANAI SHIGEO (JP)
Application Number:
PCT/JP2013/075948
Publication Date:
April 03, 2014
Filing Date:
September 25, 2013
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
International Classes:
A61K9/14; A61K31/192
Domestic Patent References:
| WO1998003505A2 | 1998-01-29 | |||
| WO2001077107A1 | 2001-10-18 | |||
| WO2000064894A1 | 2000-11-02 | |||
| WO1999046242A1 | 1999-09-16 | |||
| WO2001010826A1 | 2001-02-15 |
Foreign References:
| JP2011194366A | 2011-10-06 | |||
| JP2005177746A | 2005-07-07 | |||
| JP2011194366A | 2011-10-06 | |||
| JP2012212264A | 2012-11-01 |
Other References:
E.MERISKO-LIVERSIDGE ET AL.: "Nanosizing: a formulation approach for poorly-water-soluble compounds", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 18, 2003, pages 113 - 120, XP055101534
INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 3, no. 3, 2008, pages 295 - 309
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 18, 2003, pages 113 - 120
"Japanese Pharmacopoeia", pages: 37 - 40
JOURNAL OF ANTIBIOTICS (J. ANTIBIOTICS, vol. 38, 1985, pages 877 - 885
CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 38, 1990, pages 2792 - 2796
"39th Geotechnical workshop proceedings", June 2004, JAPANESE GEOTECHNICAL SOCIETY, pages: 2247 - 2248
"Japanese Pharmacopoeia"
SHIGEO MAEDA ET AL.: "The high-concentrated stable production of ID 100 nm-nano-bubbles by nanoGALF technology", JAPANESE SOCIETY FOR MULTIPHASE FLOW CONFERENCE, 2011
See also references of EP 2902014A4
INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 3, no. 3, 2008, pages 295 - 309
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 18, 2003, pages 113 - 120
"Japanese Pharmacopoeia", pages: 37 - 40
JOURNAL OF ANTIBIOTICS (J. ANTIBIOTICS, vol. 38, 1985, pages 877 - 885
CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 38, 1990, pages 2792 - 2796
"39th Geotechnical workshop proceedings", June 2004, JAPANESE GEOTECHNICAL SOCIETY, pages: 2247 - 2248
"Japanese Pharmacopoeia"
SHIGEO MAEDA ET AL.: "The high-concentrated stable production of ID 100 nm-nano-bubbles by nanoGALF technology", JAPANESE SOCIETY FOR MULTIPHASE FLOW CONFERENCE, 2011
See also references of EP 2902014A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
Download PDF: