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Title:
PROCESS FOR PRODUCING SOLID PARTICLES
Document Type and Number:
WIPO Patent Application WO/2014/050910
Kind Code:
A1
Abstract:
A process for producing crystals of a poorly water-soluble medicinal compound, characterized by mixing a solution of the poorly water-soluble medicinal compound in a good solvent with a nanobubbles-containing water or a nanobubbles-containing aqueous solution to precipitate crystals of the poorly water-soluble medicinal compound. The crystals of a poorly water-soluble medicinal compound which are obtained by the process are in the form of fine particles having a uniform particle diameter distribution, and exhibit excellent absorbability and persistence.

Inventors:
MURATA, Naoyuki (17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka-sh, Osaka 24, 〒5320024, JP)
YANAI, Shigeo (17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka-sh, Osaka 24, 〒5320024, JP)
Application Number:
JP2013/075948
Publication Date:
April 03, 2014
Filing Date:
September 25, 2013
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICAL COMPANY LIMITED (1-1 Doshomachi 4-chome, Chuo-ku Osaka-sh, Osaka 45, 〒5410045, JP)
International Classes:
A61K9/14; A61K31/192
Domestic Patent References:
WO1998003505A21998-01-29
WO2001077107A12001-10-18
WO2000064894A12000-11-02
WO1999046242A11999-09-16
WO2001010826A12001-02-15
Foreign References:
JP2011194366A2011-10-06
JP2005177746A2005-07-07
JP2011194366A2011-10-06
JP2012212264A2012-11-01
Other References:
E.MERISKO-LIVERSIDGE ET AL.: "Nanosizing: a formulation approach for poorly-water-soluble compounds", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 18, 2003, pages 113 - 120, XP055101534
See also references of EP 2902014A4
INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 3, no. 3, 2008, pages 295 - 309
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 18, 2003, pages 113 - 120
"Japanese Pharmacopoeia", pages: 37 - 40
JOURNAL OF ANTIBIOTICS (J. ANTIBIOTICS, vol. 38, 1985, pages 877 - 885
CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 38, 1990, pages 2792 - 2796
"39th Geotechnical workshop proceedings", June 2004, JAPANESE GEOTECHNICAL SOCIETY, pages: 2247 - 2248
"Japanese Pharmacopoeia"
SHIGEO MAEDA ET AL.: "The high-concentrated stable production of ID 100 nm-nano-bubbles by nanoGALF technology", JAPANESE SOCIETY FOR MULTIPHASE FLOW CONFERENCE, 2011
Attorney, Agent or Firm:
TAKASHIMA, Hajime (Meiji Yasuda Seimei Osaka Midosuji Bldg, 1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, 〒5410044, JP)
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