PROCESS FOR PRODUCING 5−ALKYL−&gammad −BUTYROLACTONE

WIPO Patent Application WO/2003/051856

A1

A process for producing a 5−alkyl−&gammad −butyrolactone represented by the following general formula (2): (2) wherein n is an integer of 4 or above&semi which comprises isomerizing a lactone represented by the following general formula (1): (1) wherein n is an integer of 4 or above&semi by bringing into contact with at least one acid selected from among sulfuric acid, sulfonic acid, an ion exchange resin having sulfonate group and heteropolyacid at 0 to 230°C. If needed, the thus obtained 5−alkyl−&gammad −butyrolactone is brought into contact with at least one carbonate selected form among alkali metal carbonates and alkaline earth metal carbonates. Thus, a 5−alkyl−&gammad −butyrolactone can be obtained at a relatively high yield with the use of a less expensive acid or a small amount of an acid without resort to any special reaction equipment. By treating the thus obtained 5−alkyl−&gammad −butyrolactone with the carbonate as described above, 5−alkyl−&gammad −butyrolactone with lessened odor can be obtained.

MIZOOKU TAKASHI (JP)
FUJII YASUYUKI (JP)
TAKEUCHI HIROKI (JP)
SHIMOKAWA KEISHI (JP)
MINO HARUYA (JP)

PCT/JP2002/013171

June 26, 2003

December 17, 2002

Click for automatic bibliography generation  

KAO CORP (JP)
MIZOOKU TAKASHI (JP)
FUJII YASUYUKI (JP)
TAKEUCHI HIROKI (JP)
SHIMOKAWA KEISHI (JP)
MINO HARUYA (JP)

A61K8/49; A61Q13/00; A61Q19/00; C07D307/33; A61Q3/02; (IPC1-7): C07D307/33; A61K7/46

US4611069A	1986-09-09
JPH11209363A	1999-08-03

The, Patent Corporate Body Aruga Patent Office (3-6 NIHONBASHININGYOCHO 1-CHOME CHUO-KU, Tokyo, JP)

View/Download PDF      PDF Help

Previous Patent: N,N'-DISUBSTITUTED PIPERAZINE COMPOUNDS AND THE USE OF THE SAME AS ANALGESICS

Next Patent: FURANONE SYNTHESIS