PROCESS FOR PRODUCING 4'−BROMOMETHYL−2−CYANOBIPHENYL

Title:

PROCESS FOR PRODUCING 4'−BROMOMETHYL−2−CYANOBIPHENYL

Document Type and Number:

WIPO Patent Application WO/2003/106406

Kind Code:

A1

Abstract:

A process for producing 4'−bromomethyl−2−cyanobiphenyl, characterized by reacting 4'−methyl−2−cyanobiphenyl with bromine in the presence of a free−radical initiator and an oxidizing agent. By the process, the hydrogen bromide which generates as a by−product with the progress of bromination can be converted to bromine by the action of the oxidizing agent. Troubles such as reaction inhibition by hydrogen bromide and discoloration caused by bromine can be avoided. Thus, 4'−bromomethyl−2−cyanobiphenyl, which is useful as a material for medicines, can be industrially advantageously produced.

Inventors:

YAMADA SEIJI (JP)
ISHIHARA KEN (JP)
NAKAMATSU TOSHIO (JP)

Application Number:

PCT/JP2002/012847

Publication Date:

December 24, 2003

Filing Date:

December 09, 2002

Export Citation:

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Assignee:

SUMIKA FINE CHEMICALS CO LTD (JP)
YAMADA SEIJI (JP)
ISHIHARA KEN (JP)
NAKAMATSU TOSHIO (JP)

International Classes:

C07C253/30; C07C255/50; (IPC1-7): C07C253/30; C07C255/50

Domestic Patent References:

WO1998046562A1

1998-10-22

Foreign References:

US6214999B1	2001-04-10
EP0709369A1	1996-05-01

Other References: