PROCESS FOR PRODUCTION OF 2-CYANO-3-HYDROXY-N-(4-TRI- FLUOROMETHYLPHENYL)HEPT-2-EN-6-YNAMIDE AND PROCESS FOR PRODUCTION OF POLYMORPHS THEREOF

Title:

PROCESS FOR PRODUCTION OF 2-CYANO-3-HYDROXY-N-(4-TRI- FLUOROMETHYLPHENYL)HEPT-2-EN-6-YNAMIDE AND PROCESS FOR PRODUCTION OF POLYMORPHS THEREOF

Document Type and Number:

WIPO Patent Application WO/2004/085383

Kind Code:

A1

Abstract:

Compound (I) is produced by reacting compound (II) with compound (III) or a reactive derivative thereof obtained by modification of the carboxyl group to form compound (IV) and reacting the compound (IV) with a mixed acid anhydride of compound (V). A-, B-, and C-form crystals of compound (I) can be each selectively produced by recrystallizing compound (I) under the conditions of controlled recrystallization temperature and/or controlled recrystallization (precipitation) time.

Inventors:

OMORI HIROKI (JP)
KUBOTA ARIYOSHI (JP)
KAWAKAMI TAKESHI (JP)
FUJII YOSUKE (JP)
MATSUMOTO IKUO (JP)
KITAYAMA MASATO (JP)
GOTO SHUNSUKE (JP)
HIRABAYASHI SATOSHI (JP)

Application Number:

PCT/JP2004/003904

Publication Date:

October 07, 2004

Filing Date:

March 23, 2004

Export Citation:

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Assignee:

FUJISAWA PHARMACEUTICAL CO (JP)
OMORI HIROKI (JP)
KUBOTA ARIYOSHI (JP)
KAWAKAMI TAKESHI (JP)
FUJII YOSUKE (JP)
MATSUMOTO IKUO (JP)
KITAYAMA MASATO (JP)
GOTO SHUNSUKE (JP)
HIRABAYASHI SATOSHI (JP)

International Classes:

C07C253/30; C07C253/34; C07C255/23; (IPC1-7): C07C255/23; C07C253/30; C07C253/34

Foreign References:

JPH10101636A	1998-04-21
JPH05310672A	1993-11-22

Attorney, Agent or Firm:

Nogawa, Shintaro (Nishitenma 5-chome Kita-ku, Osaka-sh, Osaka 47, JP)

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