Title:
PROCESS FOR PRODUCTION OF 2,3,4-TRIFLUORO-5-(IODO OR BROMO)BENZOIC ACID
Document Type and Number:
WIPO Patent Application WO/2006/109661
Kind Code:
A1
Abstract:
A process for producing 2,3,4-trifluoro-5-(iodo or bromo)benzoic acid, the process comprising a haloganation step in which 2,3,4-trifluorobenzoic acid is iodinated or brominated directly with an iodinating agent or brominating agent in a reaction solvent in the presence of an oxidizing agent. This process can produce 2,3,4-trifluoro-5-(iodo or bromo)benzoic acid in a simple manner in high yield, at high purity and with high stereoselectivity.
Inventors:
KOYANO HIROSHI (JP)
IIKURA HITOSHI (JP)
ISSHIKI YOSHIAKI (JP)
KOHCHI YASUNORI (JP)
IIKURA HITOSHI (JP)
ISSHIKI YOSHIAKI (JP)
KOHCHI YASUNORI (JP)
Application Number:
PCT/JP2006/307310
Publication Date:
October 19, 2006
Filing Date:
April 06, 2006
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
KOYANO HIROSHI (JP)
IIKURA HITOSHI (JP)
ISSHIKI YOSHIAKI (JP)
KOHCHI YASUNORI (JP)
KOYANO HIROSHI (JP)
IIKURA HITOSHI (JP)
ISSHIKI YOSHIAKI (JP)
KOHCHI YASUNORI (JP)
International Classes:
C07C51/363; C07C63/70; C07B61/00
Domestic Patent References:
WO1999001426A1 | 1999-01-14 | |||
WO1996002512A1 | 1996-02-01 | |||
WO2000064856A1 | 2000-11-02 |
Foreign References:
JPH1180076A | 1999-03-23 | |||
JP2002543055A | 2002-12-17 | |||
JPH1067706A | 1998-03-10 | |||
JP2000239223A | 2000-09-05 | |||
JP2003012597A | 2003-01-15 | |||
JPS6466180A | 1989-03-13 | |||
JP3573249B2 | 2004-10-06 | |||
JPS63171452A | 1988-07-15 |
Other References:
LULINSKI P. ET AL., BULL. CHEM. SOC. JPN., vol. 72, 1999, pages 115 - 120, XP003002345
SKULSKI L: "Organic iodine(I, III, and V) chemistry: 10 years of development at the medical university of Warsaw, Poland", MOLECULES, vol. 5, 2000, pages 1331 - 1371, XP003003085
See also references of EP 1870392A4
EUR. J. ORG. CHEM., 2001, pages 2771 - 2777
BULL. CHEM. SOC. JPN., vol. 70, 1997, pages 1665 - 1669
BULL. CHEM. SOC. JPN., vol. 72, 1999, pages 115 - 120
BULL. CHEM. SOC. JPN., vol. 73, 2000, pages 951 - 956
SYNTHESIS, 2004, pages 441 - 445
ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 4, 2000, pages 30 - 33
JOURNAL OF ORGANIC CHEMISTRY, vol. 53, 1988, pages 1799
SYNLETT, 1999, pages 1245
J. K. STILLE, ANGEW. CHEM., INT. ED. ENGL., vol. 25, 1986, pages 508 - 524
N. MIYAURA; A. SUZUKI, CHEM. REV., vol. 95, 1995, pages 2457 - 2483
A. SUZUKI, J. ORGANOMET. CHEM., vol. 576, 1999, pages 147 - 168
M. H. CHEN; V. G BEYLIN; E. LAKOVLEVA; S. J. KESTEN; J. MAGANO; D. DRIEZE, SYNTHETIC COMMUNICATIONS, vol. 32, no. 3, 2002, pages 411 - 417
SKULSKI L: "Organic iodine(I, III, and V) chemistry: 10 years of development at the medical university of Warsaw, Poland", MOLECULES, vol. 5, 2000, pages 1331 - 1371, XP003003085
See also references of EP 1870392A4
EUR. J. ORG. CHEM., 2001, pages 2771 - 2777
BULL. CHEM. SOC. JPN., vol. 70, 1997, pages 1665 - 1669
BULL. CHEM. SOC. JPN., vol. 72, 1999, pages 115 - 120
BULL. CHEM. SOC. JPN., vol. 73, 2000, pages 951 - 956
SYNTHESIS, 2004, pages 441 - 445
ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 4, 2000, pages 30 - 33
JOURNAL OF ORGANIC CHEMISTRY, vol. 53, 1988, pages 1799
SYNLETT, 1999, pages 1245
J. K. STILLE, ANGEW. CHEM., INT. ED. ENGL., vol. 25, 1986, pages 508 - 524
N. MIYAURA; A. SUZUKI, CHEM. REV., vol. 95, 1995, pages 2457 - 2483
A. SUZUKI, J. ORGANOMET. CHEM., vol. 576, 1999, pages 147 - 168
M. H. CHEN; V. G BEYLIN; E. LAKOVLEVA; S. J. KESTEN; J. MAGANO; D. DRIEZE, SYNTHETIC COMMUNICATIONS, vol. 32, no. 3, 2002, pages 411 - 417
Attorney, Agent or Firm:
Hasegawa, Yoshiki (Ginza First Bldg. 10-6, Ginza 1-chom, Chuo-ku Tokyo 61, JP)
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