Title:
PROCESS FOR PRODUCTION OF 4-SUBSTITUTED AZETIDINONE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2007/142207
Kind Code:
A1
Abstract:
The invention aims at producing a 4-substituted azetidinone derivative from a 4-(substituted hydroxy)azetidinone derivative efficiently and easily by an industrially advantageous process. The aim can be attained by replacing the conventional step of converting a 4-(substituted hydroxy)azetidinone derivative into a 4-acetoxyazetidinone derivative and then converting the 4-acetoxyazetidinone derivative into a 4-substituted azetidinone derivative by the step of reacting a 4-(substituted hydroxy)azetidinone derivative with an enolate of a carbonyl compound to convert the derivative into a 4-substiituted azetidinone derivative. According to the invention, a 4-(substituted hydroxy)- azetidinone derivative can be converted into a 4-substituted azetidinone derivative in one step. In particular, the use of a titanium enolate prepared from both a titanium compound and a base can make the reaction proceed with high yield.
Inventors:
HONDA TATSUYA (JP)
NAGASHIMA NOBUO (JP)
SUZUKI IKUHIRO (JP)
NAGASHIMA NOBUO (JP)
SUZUKI IKUHIRO (JP)
Application Number:
PCT/JP2007/061320
Publication Date:
December 13, 2007
Filing Date:
June 04, 2007
Export Citation:
Assignee:
KANEKA CORP (JP)
HONDA TATSUYA (JP)
NAGASHIMA NOBUO (JP)
SUZUKI IKUHIRO (JP)
HONDA TATSUYA (JP)
NAGASHIMA NOBUO (JP)
SUZUKI IKUHIRO (JP)
International Classes:
C07D413/06; C07D205/08
Domestic Patent References:
| WO1993013064A1 | 1993-07-08 |
Foreign References:
| JPH0770116A | 1995-03-14 | |||
| JPH0782248A | 1995-03-28 | |||
| JPS61275267A | 1986-12-05 | |||
| JPS62258353A | 1987-11-10 |
Other References:
KALUZA Z. ET AL.: "4-substituted 2-azetidinones, new building blocks for the synthesis of beta-lactams", SYNLETT., no. 9, 1996, pages 895 - 896, XP003020193
Attorney, Agent or Firm:
KANEKA CORPORATION (Kita-ku Osaka-shi Osaka, 88, JP)
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