Title:
PROCESS FOR PRODUCTION OF (4,5-DIHYDROISOXAZOL-3-YL)THIO- CARBOXAMIDINE SALTS
Document Type and Number:
WIPO Patent Application WO/2006/068092
Kind Code:
A1
Abstract:
The invention provides a process for producing (4,5-dihydro- isoxazol-3-yl)thiocarboxamidine salts easily and safely in a high yield which is freed from the disadvantages of the prior art. Specifically, a process for producing (4,5-dihydro- isoxazol-3-yl)thiocarboxamidine salts represented by the general formula (2): (2) [wherein R1 and R2 are each hydrogen, alkyl, or the like; R3 and R4 are each hydrogen or alkyl; or R1 and R2 or R2 and R3 together with the carbon atom(s) to which they are bonded may form cycloalkyl; and X2 is halogen or an anionic residue derived from an acid] by reacting a 3-halogeno-4,5-dihydroisoxazole represented by the general formula (1): (1) [wherein R1, R2, R3 and R4 are each as defined above; and X1 is halogeno] with thiourea in the presence of an acid.
Inventors:
UCHIDA YUKIO (JP)
Application Number:
PCT/JP2005/023270
Publication Date:
June 29, 2006
Filing Date:
December 19, 2005
Export Citation:
Assignee:
IHARA CHEMICAL IND CO (JP)
UCHIDA YUKIO (JP)
UCHIDA YUKIO (JP)
International Classes:
C07D261/04; C07D275/02; C07B61/00
Domestic Patent References:
| WO2002062770A1 | 2002-08-15 | |||
| WO2003000686A1 | 2003-01-03 | |||
| WO2005095352A1 | 2005-10-13 | |||
| WO2005105755A1 | 2005-11-10 |
Other References:
DOVLATYAN V.V. ET AL.: "Synthesis of 2-oxo-4-chloro-delta3-1,2,3-oxathiazole and its 5,5-dimethyl derivative and their conversions", ARMYANSKII KHIMICHESKII ZHURNAL, vol. 28, no. 3, 1975, pages 233 - 238, XP008063130
DOVLATYAN V.V. ET AL.: "Synthesis of 2,2-dioxo-4-chloro-1,2,3-oxathiazole-delta3 and its 5,5-dimethyl derivative and some of their transformations", ARMYANSKII KHIMICHESKII ZHURNAL, vol. 28, no. 4, 1975, pages 311 - 316, XP008063129
DOVLATYAN V.V. ET AL.: "Synthesis of pesticides. Synthesis of 1-oxo(1,1-dioxo)-3-chloro-4,4-dimethyl-delta2-1,2,5-thiadiazole and its transformations", ARMYANSKII KHIMICHESKII ZHURNAL, vol. 28, no. 5, 1975, pages 412 - 416, XP008063124
See also references of EP 1829868A4
DOVLATYAN V.V. ET AL.: "Synthesis of 2,2-dioxo-4-chloro-1,2,3-oxathiazole-delta3 and its 5,5-dimethyl derivative and some of their transformations", ARMYANSKII KHIMICHESKII ZHURNAL, vol. 28, no. 4, 1975, pages 311 - 316, XP008063129
DOVLATYAN V.V. ET AL.: "Synthesis of pesticides. Synthesis of 1-oxo(1,1-dioxo)-3-chloro-4,4-dimethyl-delta2-1,2,5-thiadiazole and its transformations", ARMYANSKII KHIMICHESKII ZHURNAL, vol. 28, no. 5, 1975, pages 412 - 416, XP008063124
See also references of EP 1829868A4
Attorney, Agent or Firm:
Senmyo, Kenji (38 Kanda-Higashimatsushitach, Chiyoda-ku Tokyo 42, JP)
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