Title:
PROCESS FOR PRODUCTION OF ADENOSINE TETRAPHOSPHATE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/150791
Kind Code:
A1
Abstract:
Disclosed is a novel process for the production of an adenosine tetraphosphate, by which an adenosine tetraphosphate can be synthesized more easily in an enhanced yield in comparison with conventional processes.
In the novel process, the synthesis of a compound of general formula (I) from a compound of general formula (XI) is conducted by converting a compound of general formula (XI) into the corresponding cyclic triphosphate compound of general formula (XIV) using a carbodiimide as a condensation agent, and then reacting the cyclic triphosphate compound with a compound of general formula (VIII) in the presence of a salt of a metal selected from among magnesium, manganese and iron.
In the formulae, Ar is aryl, X is a sulfur atom, an oxygen atom, or an imino group; R1 and R2 are each a hydrogen atom or a group selected from among alkyl groups and aralkyl groups; and M is a hydrogen atom or an ion.
Inventors:
KOGO SATORU (JP)
OSAWA KAZUOMI (JP)
HAYAKAWA HIROYUKI (JP)
OSAWA KAZUOMI (JP)
HAYAKAWA HIROYUKI (JP)
Application Number:
PCT/JP2010/060577
Publication Date:
December 29, 2010
Filing Date:
June 22, 2010
Export Citation:
Assignee:
YAMASA CORP (JP)
KOGO SATORU (JP)
OSAWA KAZUOMI (JP)
HAYAKAWA HIROYUKI (JP)
KOGO SATORU (JP)
OSAWA KAZUOMI (JP)
HAYAKAWA HIROYUKI (JP)
International Classes:
C07H19/207; A61P11/00; A61P43/00; A61K31/7076
Domestic Patent References:
| WO2008060632A2 | 2008-05-22 | |||
| WO2008012949A1 | 2008-01-31 | |||
| WO2009102928A2 | 2009-08-20 |
Foreign References:
| JP2001510484A | 2001-07-31 |
Other References:
QIANWEI HAN ET AL.: "One-Flask Synthesis of Dinucleoside Tetra- and Pentaphosphates", ORG. LETT., vol. 8, no. 10, 2006, pages 2075 - 2077, XP003020699, DOI: doi:10.1021/ol060491d
PENDERGAST W. ET AL.: "Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates", BIOORG. MED. CHEM. LETT., vol. 11, no. 2, 2001, pages 157 - 160, XP004314837, DOI: doi:10.1016/S0960-894X(00)00612-0
HYOJIN KO ET AL.: "Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 12, 2008, pages 6319 - 6332, XP022710022, DOI: doi:10.1016/j.bmc.2008.05.013
HIROAKI SAWAI ET AL.: "Mg (II) ion-mediated conversion of mono- and oligonucleotides to 5'- polyphosphates in aqueous solution", TETRAHEDRON LETTERS, vol. 34, no. 30, 1993, pages 4801 - 4804
PENDERGAST W. ET AL.: "Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates", BIOORG. MED. CHEM. LETT., vol. 11, no. 2, 2001, pages 157 - 160, XP004314837, DOI: doi:10.1016/S0960-894X(00)00612-0
HYOJIN KO ET AL.: "Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 12, 2008, pages 6319 - 6332, XP022710022, DOI: doi:10.1016/j.bmc.2008.05.013
HIROAKI SAWAI ET AL.: "Mg (II) ion-mediated conversion of mono- and oligonucleotides to 5'- polyphosphates in aqueous solution", TETRAHEDRON LETTERS, vol. 34, no. 30, 1993, pages 4801 - 4804
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