Title:
PROCESS FOR PRODUCTION OF AZULENE DERIVATIVES AND INTERMEDIATES FOR THE SYNTHESIS OF THE SAME
Document Type and Number:
WIPO Patent Application WO/2006/006496
Kind Code:
A1
Abstract:
A process for producing azulene derivatives useful as Na+-glucose cotransporter inhibitor easily and simply in high yield at a low cost which is industrially advantageous and excellent in environmental protection, characterized by subjecting at least one compound selected from among specific penta- and tetraacyl precursors of the azulene derivatives and salts of the precursors to reduction and deblocking to obtain a C-glycoside compound; and useful intermediates obtained in the above process.
Inventors:
TOMIYAMA HIROSHI (JP)
YOKOTA MASAYUKI (JP)
NODA ATSUSHI (JP)
KOBAYASHI YOSHINORI (JP)
OGASAWARA JUNKO (JP)
HAYASHI YASUMASA (JP)
INAKOSHI MASATOSHI (JP)
NAKAMURA HIROFUMI (JP)
KOIDE TOKUO (JP)
SAKAMOTO KENICHIRO (JP)
YAMASHITA YOHEI (JP)
MIYAFUJI AKIO (JP)
SUZUKI TAKAYUKI (JP)
KAWANO NORIYUKI (JP)
MIYATA JUNJI (JP)
IMAMURA MASAKAZU (JP)
SUGANE TAKASHI (JP)
YOKOTA MASAYUKI (JP)
NODA ATSUSHI (JP)
KOBAYASHI YOSHINORI (JP)
OGASAWARA JUNKO (JP)
HAYASHI YASUMASA (JP)
INAKOSHI MASATOSHI (JP)
NAKAMURA HIROFUMI (JP)
KOIDE TOKUO (JP)
SAKAMOTO KENICHIRO (JP)
YAMASHITA YOHEI (JP)
MIYAFUJI AKIO (JP)
SUZUKI TAKAYUKI (JP)
KAWANO NORIYUKI (JP)
MIYATA JUNJI (JP)
IMAMURA MASAKAZU (JP)
SUGANE TAKASHI (JP)
Application Number:
PCT/JP2005/012577
Publication Date:
January 19, 2006
Filing Date:
July 07, 2005
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
TOMIYAMA HIROSHI (JP)
YOKOTA MASAYUKI (JP)
NODA ATSUSHI (JP)
KOBAYASHI YOSHINORI (JP)
OGASAWARA JUNKO (JP)
HAYASHI YASUMASA (JP)
INAKOSHI MASATOSHI (JP)
NAKAMURA HIROFUMI (JP)
KOIDE TOKUO (JP)
SAKAMOTO KENICHIRO (JP)
YAMASHITA YOHEI (JP)
MIYAFUJI AKIO (JP)
SUZUKI TAKAYUKI (JP)
KAWANO NORIYUKI (JP)
MIYATA JUNJI (JP)
IMAMURA MASAKAZU (JP)
SUGANE TAKASHI (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
TOMIYAMA HIROSHI (JP)
YOKOTA MASAYUKI (JP)
NODA ATSUSHI (JP)
KOBAYASHI YOSHINORI (JP)
OGASAWARA JUNKO (JP)
HAYASHI YASUMASA (JP)
INAKOSHI MASATOSHI (JP)
NAKAMURA HIROFUMI (JP)
KOIDE TOKUO (JP)
SAKAMOTO KENICHIRO (JP)
YAMASHITA YOHEI (JP)
MIYAFUJI AKIO (JP)
SUZUKI TAKAYUKI (JP)
KAWANO NORIYUKI (JP)
MIYATA JUNJI (JP)
IMAMURA MASAKAZU (JP)
SUGANE TAKASHI (JP)
International Classes:
C07C43/225; C07D309/10; C07C49/223; C07H7/04; C07H15/04
Domestic Patent References:
| WO2004013118A1 | 2004-02-12 |
Foreign References:
| JP2003511458A | 2003-03-25 | |||
| JP2004359630A | 2004-12-24 |
Other References:
TOLKACHEV O N ET AL: "Synthetic studies in the curare alkaloid area. VII. Synthesis of 2-methoxy-4-(beta-acylaminoethyl)-2-alkoxy-5-carbalkoxymethyldiphenyl ethers.", ZHURNAL OBSHCHEI KHIMII., vol. 31, 1961, pages 1540 - 1545, XP002995209
See also references of EP 1783122A4
See also references of EP 1783122A4
Attorney, Agent or Firm:
Watanabe, Kazuhira (No.8 Kikuboshi Tower Building 20-18,
Asakusabashi 3-chom, Taito-ku Tokyo 53, JP)
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