Title:
PROCESS FOR PRODUCTION OF ERYTHROMYCIN A DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2004/101592
Kind Code:
A1
Abstract:
A process for producing 9-deoxo-9-hydroxyerythromycin A 11,12-cyclic carbonate derivatives useful as an intermediate in the synthesis of novel erythromycin A derivatives, which comprises reacting a compound represented by the general formula (I) with sodium borohydride in a methanol solvent containing one or two members selected from among sodium hydroxide, potassium hydroxide, sodium methoxide, sodium ethoxide, potassium methoxide, potassium ethoxide, and potassium tertiary butoxide: (I) wherein R1 is hydrogen, C1-5 alkanoyl, C1-5 alkanoyl substituted with an aromatic ring of 5 to 12 carbon atoms or a heterocycle of 3 to 9 carbon atoms, or silyl substituted with one to three groups selected from the group consisting of C1-4 alkyl, aromatic rings of 6 to 10 carbon atoms, and C1-4 alkyl groups substituted with aromatic rings of 6 to 10 carbon atoms.
Inventors:
KASHIMURA MASATO (JP)
URABE HIROKI (JP)
ADACHI TAKASHI (JP)
URABE HIROKI (JP)
ADACHI TAKASHI (JP)
Application Number:
PCT/JP2004/006985
Publication Date:
November 25, 2004
Filing Date:
May 17, 2004
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
KASHIMURA MASATO (JP)
URABE HIROKI (JP)
ADACHI TAKASHI (JP)
KASHIMURA MASATO (JP)
URABE HIROKI (JP)
ADACHI TAKASHI (JP)
International Classes:
C07H17/08; (IPC1-7): C07H17/08
Domestic Patent References:
| WO1998013373A1 | 1998-04-02 |
Foreign References:
| JPH04149152A | 1992-05-22 | |||
| JPH10500954A | 1998-01-27 | |||
| JPS58159499A | 1983-09-21 | |||
| JPH06345793A | 1994-12-20 |
Attorney, Agent or Firm:
Satori, Soichi c/o Taisho Phaemaceutical Co. (Ltd. Intellectual P roperty Division, 24-1,
Takada 3-chom, Toshima-ku Tokyo 33, JP)
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