PROCESS FOR PRODUCTION OF HETEROCYCLIC COMPOUNDS

Title:

PROCESS FOR PRODUCTION OF HETEROCYCLIC COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/2006/030892

Kind Code:

A1

Abstract:

The invention aims at providing a process for the production of NS-220 which is suitable for mass production on an industrial scale. The invention is constituted of (1) a process for the production of methyl cis-5-(4-chlorobutyl) -2-methyl-1,3-dioxane-2-carboxylate, characterized by hydrolyzing a cis/trans isomer mixture of methyl 5-(4- chlorobutyl)-2-methyl-1,3-dioxane-2-carboxylate in the presence of a base; (2) a process for the production of 4-methyl-N-(2-oxopropyl)benzamide, characterized by oxidizing 4-methyl-N-(2-hydroxypropyl)benzamide with 2,2,6,6-tetra- methyl-1-piperidinyloxyl radicals and sodium hypochlorite; and so on.

Inventors:

HARABE TETSUJI (JP)
TANAKA MASARU (JP)

Application Number:

PCT/JP2005/017137

Publication Date:

March 23, 2006

Filing Date:

September 16, 2005

Export Citation:

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Assignee:

NIPPON SHINYAKU CO LTD (JP)
HARABE TETSUJI (JP)
TANAKA MASARU (JP)

International Classes:

C07D319/06; C07C231/12; C07C233/76; C07D413/06

Domestic Patent References:

WO2001090087A1

2001-11-29

Foreign References:

JP2002522557A	2002-07-23
JP2002522554A	2002-07-23
JP2004217608A	2004-08-05

Other References:

KUWABARA K.: "A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice.", J PHARMACOL EXP THER., vol. 309, no. 3, June 2004 (2004-06-01), pages 970 - 977, XP002995210

Attorney, Agent or Firm:

Shimizu, Naoto (Intellectual Property Dept.,, 14, Nisshoin Nishinosho Monguchicho,, Minami-ku, Kyoto-sh, Kyoto, JP)

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