Title:
PROCESS FOR PRODUCTION OF IODINE COMPOUNDS AND PROCESS FOR PRODUCTION OF HIGH-PURITY 5-IODO-2-METHYLBENZOIC ACID
Document Type and Number:
WIPO Patent Application WO/2004/069772
Kind Code:
A1
Abstract:
A process for the production of iodine compounds by reacting iodine with a substrate either in the presence of a porous compound having a pore diameter of 500 nm or below or in the presence of such a porous compound and an oxidizing agent; and a process for the production of high-purity 5-iodo-2-methyl- benzoic acid which comprises the iodination step according to the above process, the crystallization/separation step of precipitating the reaction product either by the addition of water or by cooling and separating the precipitated crystalline substance, and the purification step of recrystallizing the crystalline substance from an organic solvent. According to the former process, iodine can be introduced into various substrates with high selectivity without using any expensive metal or any special reagent, so that the process can be easily carried out industrially and can give high-purity products. According to the latter process, 5-iodo-2-methylbenzoic acid useful in the field of functional chemicals such as drugs can be easily produced at high purity and in high yield. The processes are easy and simple and are characterized by small purification load and so on, thus being very advantageous to carry out industrially.
Inventors:
HIDAKA TOSHIO (JP)
YOSHIMURA TAKAFUMI (JP)
SATO YOSHIFUMI (JP)
FUSHIMI NORIO (JP)
DOYA MASAHARU (JP)
YOSHIMURA TAKAFUMI (JP)
SATO YOSHIFUMI (JP)
FUSHIMI NORIO (JP)
DOYA MASAHARU (JP)
Application Number:
PCT/JP2004/001367
Publication Date:
August 19, 2004
Filing Date:
February 10, 2004
Export Citation:
Assignee:
MITSUBISHI GAS CHEMICAL CO (JP)
HIDAKA TOSHIO (JP)
YOSHIMURA TAKAFUMI (JP)
SATO YOSHIFUMI (JP)
FUSHIMI NORIO (JP)
DOYA MASAHARU (JP)
HIDAKA TOSHIO (JP)
YOSHIMURA TAKAFUMI (JP)
SATO YOSHIFUMI (JP)
FUSHIMI NORIO (JP)
DOYA MASAHARU (JP)
International Classes:
C07B39/00; C07C17/12; C07C17/156; C07C17/158; C07C51/363; C07C51/43; (IPC1-7): C07B39/00; C07C17/12; C07C25/02; C07C25/18; C07C51/363; C07C51/43; C07C63/70; C07C253/30; C07C255/50
Foreign References:
| JPH08157394A | 1996-06-18 | |||
| JPS59219241A | 1984-12-10 | |||
| JPH03503412A | 1991-08-01 | |||
| JPH01502819A | 1989-09-28 | |||
| JP2003012597A | 2003-01-15 |
Other References:
See also references of EP 1595862A4
JAPAN, vol. 72, 1999, pages 115
ZH. OBSCH. KHIM. OBSHCHEST, vol. 17, 1972, pages 464
J. AM. CHEM. SOC., vol. 90, 1968, pages 6187
JAPAN, vol. 72, 1999, pages 115
ZH. OBSCH. KHIM. OBSHCHEST, vol. 17, 1972, pages 464
J. AM. CHEM. SOC., vol. 90, 1968, pages 6187
Attorney, Agent or Firm:
Ohtani, Tamotsu (25-2 Toranomon 3-chom, Minato-ku Tokyo, JP)
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