Title:
PROCESS FOR PRODUCTION OF NANOPARTICLES AND MICROPARTICLES BY SPRAY FREEZING INTO LIQUID
Document Type and Number:
WIPO Patent Application WO2002060411
Kind Code:
A3
Abstract:
The present invention provides a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased porosity and a more intimate mixing of the particle components. The system and method of the present invention also produce particles with greater surface area than conventional methods. One form of the present invention provides a method for the preparation of particles. An effective ingredient is mixed with water, one or more solvents, or a combination thereof, and the resulting mixture is sprayed through an insulating nozzle located at or below the level of a cryogenic liquid. The spray generates frozen particles.
Inventors:
WILLIAMS ROBERT O III
JOHNSTON KEITH P
YOUNG TIMOTHY J
ROGERS TRUE L
BARRON MELISA K
YU ZHONGSHUI
HU JIAHUI
JOHNSTON KEITH P
YOUNG TIMOTHY J
ROGERS TRUE L
BARRON MELISA K
YU ZHONGSHUI
HU JIAHUI
Application Number:
PCT/US2002/002894
Publication Date:
February 27, 2003
Filing Date:
January 30, 2002
Export Citation:
Assignee:
UNIV TEXAS (US)
International Classes:
A61K9/14; A61K9/16; A61K31/55; A61J3/02; A61K31/58; A61K38/23; A61K38/28; A61P3/10; A61P3/14; A61P5/44; A61P13/00; A61P25/08; A61P35/00; B01J19/00; F25C1/00; F26B3/08; F26B5/06; F25B19/00; (IPC1-7): A61K9/16; A61K9/19; F26B5/06
Domestic Patent References:
| WO1990013285A1 | 1990-11-15 |
Other References:
HELLER M C ET AL: "Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separation.", BIOTECHNOLOGY AND BIOENGINEERING. UNITED STATES 20 APR 1999, vol. 63, no. 2, 20 April 1999 (1999-04-20), pages 166 - 174, XP002219001, ISSN: 0006-3592
MAA Y-F ET AL: "PROTEIN INHALATION POWDERS: SPRAY DRYING VS SPRAY FREEZE DRYING", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 16, no. 2, 1999, pages 249 - 254, XP001002270, ISSN: 0724-8741
DIXON D J ET AL: "POLYMERIC MATERIALS FORMED BY PRECIPITATION WITH A COMPRESSED FLUID ANTISOLVENT", AICHE JOURNAL, NEW YORK, NY, US, vol. 39, no. 1, November 1993 (1993-11-01), pages 127 - 139, XP000965706, ISSN: 0001-1541
ROGERS T.L. ET AL: "Solution-based particle formation of pharmaceutical powders by supercritical or compressed fluid CO(2) and cryogenic spray -freezing technologies.", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, (2001) 27/10 (1003-1015)., XP001119435
MAA Y-F ET AL: "PROTEIN INHALATION POWDERS: SPRAY DRYING VS SPRAY FREEZE DRYING", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 16, no. 2, 1999, pages 249 - 254, XP001002270, ISSN: 0724-8741
DIXON D J ET AL: "POLYMERIC MATERIALS FORMED BY PRECIPITATION WITH A COMPRESSED FLUID ANTISOLVENT", AICHE JOURNAL, NEW YORK, NY, US, vol. 39, no. 1, November 1993 (1993-11-01), pages 127 - 139, XP000965706, ISSN: 0001-1541
ROGERS T.L. ET AL: "Solution-based particle formation of pharmaceutical powders by supercritical or compressed fluid CO(2) and cryogenic spray -freezing technologies.", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, (2001) 27/10 (1003-1015)., XP001119435
Download PDF: