Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE 3-PHENYLISOSERINE
Document Type and Number:
WIPO Patent Application WO2003003804
Kind Code:
A3
Abstract:
The invention relates to a process for the preparation of (R, R)-phenylisoserine and its derivatives. The process according to the invention includes the following steps : - reacting a 3-phenylglycidic acid salt with ammonia to yield the salt of racemic phenylisoserine, - converting the salt of racemic phenylisoserine to racemic phenylisoserine 1-4C- alkyl ester and - separating the (R,R)-phenylisoserine 1-4C-alkyl ester from the racemate by reacting the latter with L- (+)-tartaric acid and working the salt obtained for (R,R) -phenylisoserine 1-4C-alkyl ester. Likewise, D-(-)-tartaric acid can be used in order to obtain (S,S)-phenylisoserine ethyl ester in high optical purity.

Inventors:
FABER WIJNAND (NL)
KOEK JAN (NL)
SENN-BILFINGER JOERG (DE)
VRIES TON (NL)
Application Number:
PCT/EP2002/007092
Publication Date:
July 01, 2004
Filing Date:
June 27, 2002
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
ALTANA PHARMA AG (DE)
FABER WIJNAND (NL)
KOEK JAN (NL)
SENN-BILFINGER JOERG (DE)
VRIES TON (NL)
International Classes:
C07B57/00; C07C22/00; C07C227/06; C07C227/08; C07C227/18; C07C227/34; C07C229/34; C07C229/36; (IPC1-7): C07C227/34; C07C227/06; C07C229/34
Foreign References:
US6025516A2000-02-15
Other References:
KAORU HARADA: "Optical Resolution and Absolute Configuration of trans -.beta.-Phenylglycidic acid", J. ORG. CHEM., vol. 31, 1966, pages 1407 - 10, XP002140516
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002183960, Database accession no. BRN 2938805
CHEMICAL ABSTRACTS, vol. 133, no. 1, 2000, Columbus, Ohio, US; abstract no. 4819, YU, GUANG'UO ET AL: "Synthesis of (2S, 3S) and (2R, 3R) isomer of taxol side chain" page 599; XP002183959
Download PDF: