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Title:
PROCESS FOR THE PRODUCTION OF OXANDROLONE
Document Type and Number:
WIPO Patent Application WO2004064722
Kind Code:
A3
Abstract:
The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form 17beta -hydroxy-17alpha -methyl-5 -androst-1-en-3-one; (b) hydroxylating the 17beta - hydroxy-17alpha -methyl-5alpha -androst-1-en-3-one to form 1alpha , 2alpha , 17beta -trihydroxy-17alpha - methylandrostan-3-one; (c) cleaving the 1alpha , 2alpha , 17beta -trihydroxy-17alpha -methylandrostan-3- one to form 17beta -hydroxy-17alpha -methyl-1-oxo-1,2,-seco-A-nor-5 -androstan-2-oic acid; and (d) reducing the 17beta -hydroxy-17 -methyl-1-oxo-1,2,-seco-A-nor-5alpha -androstan-2-oic acid to form oxandrolone.

Inventors:
DESAI SHAILESHKUMAR RAMANLAL
RAY DAVID WAYNE JR
SAYED YOUSRY A
Application Number:
PCT/US2002/039673
Publication Date:
November 18, 2004
Filing Date:
December 11, 2002
Export Citation:
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Assignee:
ENDEAVOR PHARMACEUTICALS INC (US)
International Classes:
C07D311/78; C07D311/94; C07J1/00; C07J73/00; (IPC1-7): C07D321/00; C07D309/00; C07D311/78; C07D311/94
Foreign References:
US3128283A1964-04-07
Other References:
BI H. ET AL: "Studies on anabolic steroids. 9. Tertiary sulfates of anabolic 17alpha-methyl steroids: synthesis and rearrangement", STEROIDS, vol. 57, July 1992 (1992-07-01), pages 306 - 312, XP002981298
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