Title:
PROCESS FOR PRODUCTION OF STYRENE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2008/010578
Kind Code:
A1
Abstract:
A process for producing a styrene derivative represented by the general formula (III), particularly 5-(3-ethoxy- 3-oxopropyl)-7,8-dihydronaphthalen-1-yl pivalate with efficiency, comprising conducting a coupling reaction of a compound represented by the general formula (I) with a compound represented by the general formula (II) in a non-aqueous solvent in the presence of a catalytic amount of a phosphine complex of nickel or palladium, particularly a phosphine complex of nickel. The styrene derivative is useful as an intermediate for the synthesis of various pharmaceutical agents. (I)(II) (III) wherein each symbol is as defined in the description.
Inventors:
KUWABE SHIN-ITSU (JP)
MASAOKA HIDEO (JP)
GISELBRECHT KARL-HEINZ (AT)
HIEBL JOHANN (AT)
REITER KLAUS (AT)
SKRANC WOLFGANG (AT)
DE VRIES ANDRE HENDRIKUS MARIA (NL)
DE VRIES JOHANNES GERARDUS (NL)
MASAOKA HIDEO (JP)
GISELBRECHT KARL-HEINZ (AT)
HIEBL JOHANN (AT)
REITER KLAUS (AT)
SKRANC WOLFGANG (AT)
DE VRIES ANDRE HENDRIKUS MARIA (NL)
DE VRIES JOHANNES GERARDUS (NL)
Application Number:
PCT/JP2007/064364
Publication Date:
January 24, 2008
Filing Date:
July 20, 2007
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
KUWABE SHIN-ITSU (JP)
MASAOKA HIDEO (JP)
GISELBRECHT KARL-HEINZ (AT)
HIEBL JOHANN (AT)
REITER KLAUS (AT)
SKRANC WOLFGANG (AT)
DE VRIES ANDRE HENDRIKUS MARIA (NL)
DE VRIES JOHANNES GERARDUS (NL)
KUWABE SHIN-ITSU (JP)
MASAOKA HIDEO (JP)
GISELBRECHT KARL-HEINZ (AT)
HIEBL JOHANN (AT)
REITER KLAUS (AT)
SKRANC WOLFGANG (AT)
DE VRIES ANDRE HENDRIKUS MARIA (NL)
DE VRIES JOHANNES GERARDUS (NL)
International Classes:
C07C67/30; C07C69/63; C07D263/32; C07B61/00; C07C69/608
Domestic Patent References:
| WO2005103017A1 | 2005-11-03 |
Foreign References:
| JP2001261585A | 2001-09-26 |
Other References:
ORSINI F. AND PELLIZZONI F.: "Pd(0)-MEDIATED CROSS-COUPLING OF REFORMATSKY REAGENTS WITH VINYL- AND ARYL TRIFLATES", SYNTHETIC COMMUNICATION, vol. 17, no. 12, 1987, pages 1389 - 1402, XP003020475
THE CHEMICAL SOCIETY OF JAPAN: "Jikken Kagaku Koza 18, Yuki Kagobutsu no Gosei VI -Kinzoku o Mochiiru Yuki Gosei-", vol. 5TH ED., 10 September 2004, MARUZEN CO., LTD., pages: 327 - 332, XP003020476
THE CHEMICAL SOCIETY OF JAPAN: "Jikken Kagaku Koza 18, Yuki Kagobutsu no Gosei VI -Kinzoku o Mochiiru Yuki Gosei-", vol. 5TH ED., 10 September 2004, MARUZEN CO., LTD., pages: 327 - 332, XP003020476
Attorney, Agent or Firm:
OHIE, Kunihisa et al. (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chome, Chuo-k, Tokyo 13, JP)
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