Title:
PROCESS AND REACTOR FOR THE MANUFACTURE OF POWDERS OF INHALABLE MEDICAMENTS
Document Type and Number:
WIPO Patent Application WO2004034943
Kind Code:
A3
Abstract:
The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactor(a) a segmented flow of that fluid comprised of discrete volumes; or(b) a fluid mixture being separated by discrete volumes of a separating fluid which is substantially immiscible with said fluid,characterized in that the crystallization is initiated by application of ultrasound.
Inventors:
JONGEN NATHALIE (CH)
LEMAITRE JACQUES (CH)
BOWEN PAUL (CH)
DONNET MARCEL (CH)
SCHIEWE JOERG (DE)
ZIERENBERG BERND (DE)
SOARE LUCICA CRISTINA (CH)
LEMAITRE JACQUES (CH)
BOWEN PAUL (CH)
DONNET MARCEL (CH)
SCHIEWE JOERG (DE)
ZIERENBERG BERND (DE)
SOARE LUCICA CRISTINA (CH)
Application Number:
PCT/EP2003/011010
Publication Date:
May 27, 2004
Filing Date:
October 06, 2003
Export Citation:
Assignee:
BOEHRINGER INGELHEIM PHARMA (DE)
ECOLE POLYTECH (CH)
JONGEN NATHALIE (CH)
LEMAITRE JACQUES (CH)
BOWEN PAUL (CH)
DONNET MARCEL (CH)
SCHIEWE JOERG (DE)
ZIERENBERG BERND (DE)
SOARE LUCICA CRISTINA (CH)
ECOLE POLYTECH (CH)
JONGEN NATHALIE (CH)
LEMAITRE JACQUES (CH)
BOWEN PAUL (CH)
DONNET MARCEL (CH)
SCHIEWE JOERG (DE)
ZIERENBERG BERND (DE)
SOARE LUCICA CRISTINA (CH)
International Classes:
A61K9/00; A61K9/16; B01D9/00; B01F13/00; B01J2/06; B01J19/00; B01J19/10; (IPC1-7): B01D9/00; B01J2/06; B01J19/00; B01J19/10; A61K9/16
Domestic Patent References:
| WO2002089942A1 | 2002-11-14 | |||
| WO1998002237A1 | 1998-01-22 | |||
| WO2002000200A1 | 2002-01-03 | |||
| WO2000038811A1 | 2000-07-06 |
Foreign References:
| DE1262240B | 1968-03-07 |
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