Title:
PROCESS-SCALE SYNTHESIS OF UROLITHINS
Document Type and Number:
WIPO Patent Application WO/2015/100213
Kind Code:
A3
Abstract:
Disclosed is a method of preparing a urolithin, or an intermediate or analog thereof, having a dibenzo[b,d]pyran-6-one core. The method is especially advantageous for the large-scale preparation of urolithins or intermediates or analogs thereof. The method may optionally include the preparation of a urolithin, or an intermediate or analog thereof, as a pharmaceutically acceptable salt.
Inventors:
RINSCH CHRISTPOHER L (CH)
MÜLLER ROLAND (DE)
SKRANC WOLFGANG (AT)
MÜLLER ROLAND (DE)
SKRANC WOLFGANG (AT)
Application Number:
PCT/US2014/071824
Publication Date:
September 17, 2015
Filing Date:
December 22, 2014
Export Citation:
Assignee:
AMAZENTIS SA (CH)
RINSCH CHRISTPOHER L (CH)
RINSCH CHRISTPOHER L (CH)
International Classes:
C07D311/80
Foreign References:
| EP2674422A1 | 2013-12-18 |
Other References:
MACIEJ KRZESZEWSKI ET AL: "Color-Tunable Fluorescent Dyes Based on Benzo[ c ]coumarin", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2013, no. 25, 16 September 2013 (2013-09-16), pages 5631 - 5644, XP055174487, ISSN: 1434-193X, DOI: 10.1002/ejoc.201300374
SUN WANYING ET AL: "6H-Benzo[c]chromen-6-one derivatives as selective ER[beta] agon", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 6, 18 January 2006 (2006-01-18), pages 1468 - 1472, XP028755073, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2005.12.057
JAYA PANDEY ET AL: "Synthesis and biological activities of some new dibenzopyranones and dibenzopyrans: search for potential oestrogen receptor agonists and antagonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, no. 9, 1 January 2004 (2004-01-01), pages 2239 - 2249, XP055100310, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2004.02.018
UDO KRAATZ ET AL: "Zur Synthese von Phenanthridinonen-(6) aus 3.4-disubstituierten Cumarinen und ihre Reaktion mit Methylmagnesiumjodid zu Phenanthridiniumjodiden", CHEMISCHE BERICHTE, vol. 106, no. 1, 1 January 1973 (1973-01-01), pages 62 - 68, XP055172175, ISSN: 0009-2940, DOI: 10.1002/cber.19731060110
KAZUHIRO KUDO ET AL: "Scalable Synthesis of 8-Amino-3-hydroxy-6 H -benzo[ c ]chromen-6-one: Key Intermediate for SEGRA via the Hurtley Reaction", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 19, no. 1, 11 December 2014 (2014-12-11), pages 309 - 314, XP055174456, ISSN: 1083-6160, DOI: 10.1021/op500334b
SUN WANYING ET AL: "6H-Benzo[c]chromen-6-one derivatives as selective ER[beta] agon", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 6, 18 January 2006 (2006-01-18), pages 1468 - 1472, XP028755073, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2005.12.057
JAYA PANDEY ET AL: "Synthesis and biological activities of some new dibenzopyranones and dibenzopyrans: search for potential oestrogen receptor agonists and antagonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, no. 9, 1 January 2004 (2004-01-01), pages 2239 - 2249, XP055100310, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2004.02.018
UDO KRAATZ ET AL: "Zur Synthese von Phenanthridinonen-(6) aus 3.4-disubstituierten Cumarinen und ihre Reaktion mit Methylmagnesiumjodid zu Phenanthridiniumjodiden", CHEMISCHE BERICHTE, vol. 106, no. 1, 1 January 1973 (1973-01-01), pages 62 - 68, XP055172175, ISSN: 0009-2940, DOI: 10.1002/cber.19731060110
KAZUHIRO KUDO ET AL: "Scalable Synthesis of 8-Amino-3-hydroxy-6 H -benzo[ c ]chromen-6-one: Key Intermediate for SEGRA via the Hurtley Reaction", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 19, no. 1, 11 December 2014 (2014-12-11), pages 309 - 314, XP055174456, ISSN: 1083-6160, DOI: 10.1021/op500334b
Attorney, Agent or Firm:
GORDON, Dana, M. et al. (Patent Group155 Seaport Boulevar, Boston MA, US)
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